Dispersive data from rheometer for both phantoms.
<div><p>This study designed a novel shear wave Time of Flight (TOF) device to measure frequency-dependent shear wave velocity in tissue-mimicking materials, from which viscoelastic parameters were estimated through Kelvin-Voigt fractional derivative modeling to establish a reliable calib...
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2025
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| _version_ | 1852014897111498752 |
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| author | Jotham Josephat Kimondo (19139409) |
| author2 | Yi Hu (58993) Junjie Xue (1265085) Bangyi Luo (22614727) Ziang Feng (22614730) Jun Wu (4002) Zhe Wu (582498) |
| author2_role | author author author author author author |
| author_facet | Jotham Josephat Kimondo (19139409) Yi Hu (58993) Junjie Xue (1265085) Bangyi Luo (22614727) Ziang Feng (22614730) Jun Wu (4002) Zhe Wu (582498) |
| author_role | author |
| dc.creator.none.fl_str_mv | Jotham Josephat Kimondo (19139409) Yi Hu (58993) Junjie Xue (1265085) Bangyi Luo (22614727) Ziang Feng (22614730) Jun Wu (4002) Zhe Wu (582498) |
| dc.date.none.fl_str_mv | 2025-11-13T18:24:19Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0335645.s001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Dispersive_data_from_rheometer_for_both_phantoms_/30611659 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biophysics Medicine Physiology Biotechnology Space Science Biological Sciences not elsewhere classified Physical Sciences not elsewhere classified reliable calibration standard mechanical properties modulated immediate clinical relevance elastography calibration standard custom algorithm based captured shear waves calibrating clinical elastography bimorph transducers operating >&# 951 ;</ >&# 945 ;</ parameters across techniques nonoverlapping frequency ranges damping effects accounted constrained tof refit ex vivo validation div >< p >< sub >< kvfd forward model damping effects vivo performance viscous parameters viscoelastic parameters tunable alternative thaw cycling study designed strongly dependent spatial heterogeneity soft phantoms soft phantom primarily stem previous studies present study polyvinyl alcohol poisson ’ phantom standardization performed band percent differences mimicking phantoms mimicking materials methodological bias method assessment measurement band measure frequency key limitations inversion model future evaluation frequency sensitive fractional order findings support fair cross |
| dc.title.none.fl_str_mv | Dispersive data from rheometer for both phantoms. |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | <div><p>This study designed a novel shear wave Time of Flight (TOF) device to measure frequency-dependent shear wave velocity in tissue-mimicking materials, from which viscoelastic parameters were estimated through Kelvin-Voigt fractional derivative modeling to establish a reliable calibration standard. Tissue-mimicking phantoms were fabricated using 10 wt% polyvinyl alcohol (PVA) and 2 wt% α-alumina powder, with mechanical properties modulated through freeze-thaw cycling. Bimorph transducers operating in the 40–180 Hz range induced and captured shear waves. A single-cycle sine wave excitation ensures narrowband propagation, and a custom algorithm based on the cumulative energy technique robustly detects the shear wave arrival time to estimate TOF. Frequency-dependent shear velocity data were fitted to the Kelvin Voigt fractional derivative (KVFD) model to derive the relaxed elastic modulus (<i><i>E</i></i><sub><i>o</i></sub>), viscosity (η), and fractional order (α), with Poisson’s ratio and damping effects accounted for in the model assumptions. The fitting demonstrated high accuracy, with an R<sup>²</sup> value of 98.8% (RMSE = 0.013 m/s) for the hard phantom and 99.1% (RMSE = 0.002 m/s) for the soft phantom. Validation with standard rheometer data showed reasonable agreement in elasticity, with percent differences of 2.1% for the hard and 13.3% for the soft phantoms. The latter reflects greater sensitivity to damping effects and assumptions on Poisson’s ratio, as reported in previous studies. However, η and α showed larger deviations because they are strongly dependent on the measurement band; therefore, a direct comparison of these parameters across techniques with nonoverlapping frequency ranges is inappropriate. To enable a fair cross-method assessment, we performed band-matched velocity domain projections in both directions using the KVFD forward model and a constrained TOF refit with <i><i>E</i></i><sub><i>o</i></sub> fixed to the rheometer value. This analysis revealed that the discrepancies in <i>η</i> and <i>α</i> primarily stem from frequency band sensitivity rather than methodological bias. These findings support the shear wave TOF device as a robust, frequency-tunable alternative to rheometry for ex vivo tissue characterization and for calibrating clinical elastography. Its immediate clinical relevance is to provide a rapid and low-cost approach for phantom standardization and to inform elastography parameter settings. Key limitations of the present study are the restriction to ex vivo validation, operation within 40–180 Hz, and use of a dispersion-only inversion model; consequently, the viscous parameters <i>(η, α)</i> are frequency sensitive and not directly comparable to low-frequency rheometry. Future evaluation of in vivo performance and spatial heterogeneity is therefore essential.</p></div> |
| eu_rights_str_mv | openAccess |
| id | Manara_e331cfc8ffe04f2f971fc437e7c69ef7 |
| identifier_str_mv | 10.1371/journal.pone.0335645.s001 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30611659 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Dispersive data from rheometer for both phantoms.Jotham Josephat Kimondo (19139409)Yi Hu (58993)Junjie Xue (1265085)Bangyi Luo (22614727)Ziang Feng (22614730)Jun Wu (4002)Zhe Wu (582498)BiophysicsMedicinePhysiologyBiotechnologySpace ScienceBiological Sciences not elsewhere classifiedPhysical Sciences not elsewhere classifiedreliable calibration standardmechanical properties modulatedimmediate clinical relevanceelastography calibration standardcustom algorithm basedcaptured shear wavescalibrating clinical elastographybimorph transducers operating>&# 951 ;</>&# 945 ;</parameters across techniquesnonoverlapping frequency rangesdamping effects accountedconstrained tof refitex vivo validationdiv >< p>< sub ><kvfd forward modeldamping effectsvivo performanceviscous parametersviscoelastic parameterstunable alternativethaw cyclingstudy designedstrongly dependentspatial heterogeneitysoft phantomssoft phantomprimarily stemprevious studiespresent studypolyvinyl alcoholpoisson ’phantom standardizationperformed bandpercent differencesmimicking phantomsmimicking materialsmethodological biasmethod assessmentmeasurement bandmeasure frequencykey limitationsinversion modelfuture evaluationfrequency sensitivefractional orderfindings supportfair cross<div><p>This study designed a novel shear wave Time of Flight (TOF) device to measure frequency-dependent shear wave velocity in tissue-mimicking materials, from which viscoelastic parameters were estimated through Kelvin-Voigt fractional derivative modeling to establish a reliable calibration standard. Tissue-mimicking phantoms were fabricated using 10 wt% polyvinyl alcohol (PVA) and 2 wt% α-alumina powder, with mechanical properties modulated through freeze-thaw cycling. Bimorph transducers operating in the 40–180 Hz range induced and captured shear waves. A single-cycle sine wave excitation ensures narrowband propagation, and a custom algorithm based on the cumulative energy technique robustly detects the shear wave arrival time to estimate TOF. Frequency-dependent shear velocity data were fitted to the Kelvin Voigt fractional derivative (KVFD) model to derive the relaxed elastic modulus (<i><i>E</i></i><sub><i>o</i></sub>), viscosity (η), and fractional order (α), with Poisson’s ratio and damping effects accounted for in the model assumptions. The fitting demonstrated high accuracy, with an R<sup>²</sup> value of 98.8% (RMSE = 0.013 m/s) for the hard phantom and 99.1% (RMSE = 0.002 m/s) for the soft phantom. Validation with standard rheometer data showed reasonable agreement in elasticity, with percent differences of 2.1% for the hard and 13.3% for the soft phantoms. The latter reflects greater sensitivity to damping effects and assumptions on Poisson’s ratio, as reported in previous studies. However, η and α showed larger deviations because they are strongly dependent on the measurement band; therefore, a direct comparison of these parameters across techniques with nonoverlapping frequency ranges is inappropriate. To enable a fair cross-method assessment, we performed band-matched velocity domain projections in both directions using the KVFD forward model and a constrained TOF refit with <i><i>E</i></i><sub><i>o</i></sub> fixed to the rheometer value. This analysis revealed that the discrepancies in <i>η</i> and <i>α</i> primarily stem from frequency band sensitivity rather than methodological bias. These findings support the shear wave TOF device as a robust, frequency-tunable alternative to rheometry for ex vivo tissue characterization and for calibrating clinical elastography. Its immediate clinical relevance is to provide a rapid and low-cost approach for phantom standardization and to inform elastography parameter settings. Key limitations of the present study are the restriction to ex vivo validation, operation within 40–180 Hz, and use of a dispersion-only inversion model; consequently, the viscous parameters <i>(η, α)</i> are frequency sensitive and not directly comparable to low-frequency rheometry. Future evaluation of in vivo performance and spatial heterogeneity is therefore essential.</p></div>2025-11-13T18:24:19ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.1371/journal.pone.0335645.s001https://figshare.com/articles/dataset/Dispersive_data_from_rheometer_for_both_phantoms_/30611659CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/306116592025-11-13T18:24:19Z |
| spellingShingle | Dispersive data from rheometer for both phantoms. Jotham Josephat Kimondo (19139409) Biophysics Medicine Physiology Biotechnology Space Science Biological Sciences not elsewhere classified Physical Sciences not elsewhere classified reliable calibration standard mechanical properties modulated immediate clinical relevance elastography calibration standard custom algorithm based captured shear waves calibrating clinical elastography bimorph transducers operating >&# 951 ;</ >&# 945 ;</ parameters across techniques nonoverlapping frequency ranges damping effects accounted constrained tof refit ex vivo validation div >< p >< sub >< kvfd forward model damping effects vivo performance viscous parameters viscoelastic parameters tunable alternative thaw cycling study designed strongly dependent spatial heterogeneity soft phantoms soft phantom primarily stem previous studies present study polyvinyl alcohol poisson ’ phantom standardization performed band percent differences mimicking phantoms mimicking materials methodological bias method assessment measurement band measure frequency key limitations inversion model future evaluation frequency sensitive fractional order findings support fair cross |
| status_str | publishedVersion |
| title | Dispersive data from rheometer for both phantoms. |
| title_full | Dispersive data from rheometer for both phantoms. |
| title_fullStr | Dispersive data from rheometer for both phantoms. |
| title_full_unstemmed | Dispersive data from rheometer for both phantoms. |
| title_short | Dispersive data from rheometer for both phantoms. |
| title_sort | Dispersive data from rheometer for both phantoms. |
| topic | Biophysics Medicine Physiology Biotechnology Space Science Biological Sciences not elsewhere classified Physical Sciences not elsewhere classified reliable calibration standard mechanical properties modulated immediate clinical relevance elastography calibration standard custom algorithm based captured shear waves calibrating clinical elastography bimorph transducers operating >&# 951 ;</ >&# 945 ;</ parameters across techniques nonoverlapping frequency ranges damping effects accounted constrained tof refit ex vivo validation div >< p >< sub >< kvfd forward model damping effects vivo performance viscous parameters viscoelastic parameters tunable alternative thaw cycling study designed strongly dependent spatial heterogeneity soft phantoms soft phantom primarily stem previous studies present study polyvinyl alcohol poisson ’ phantom standardization performed band percent differences mimicking phantoms mimicking materials methodological bias method assessment measurement band measure frequency key limitations inversion model future evaluation frequency sensitive fractional order findings support fair cross |