Localization of delivered AGAT and GAMT in WT fibroblasts.
<p>Immunofluorescence (IF) of WT fibroblasts stably expressing AGAT + GAMT and empty vector infected controls imaged at 63x magnification. N = 4. Scale bars indicate 10 µm.</p>
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , |
| منشور في: |
2025
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1852020628583874560 |
|---|---|
| author | Chloe Wells (17231887) |
| author2 | Jon Sorgenfrei (21273708) Sadie L. Johnson (21273711) Devin Albertson (21273714) Jared Rutter (2128906) Steven Andrew Baker (10150952) |
| author2_role | author author author author author |
| author_facet | Chloe Wells (17231887) Jon Sorgenfrei (21273708) Sadie L. Johnson (21273711) Devin Albertson (21273714) Jared Rutter (2128906) Steven Andrew Baker (10150952) |
| author_role | author |
| dc.creator.none.fl_str_mv | Chloe Wells (17231887) Jon Sorgenfrei (21273708) Sadie L. Johnson (21273711) Devin Albertson (21273714) Jared Rutter (2128906) Steven Andrew Baker (10150952) |
| dc.date.none.fl_str_mv | 2025-05-08T17:50:44Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0319350.g003 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Localization_of_delivered_AGAT_and_GAMT_in_WT_fibroblasts_/28964382 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biochemistry Medicine Cell Biology Genetics Molecular Biology Mental Health target cell types natural cellular compartment highly energetic tissues critical metabolite used affected individuals suffer creatine uptake relies creatine transporter 1 healthy control fibroblasts endogenous creatine synthesis div >< p intracellular creatine concentrations intracellular synthesis transport creatine primary fibroblasts patient fibroblasts intracellular concentration slc6a8 </ selectively expressed protein product proper targeting phenotypes referred linked gene like behaviors intellectual disability hek293t cells genetic defects gene therapy gatm </ function mutations far exceeding effective therapies common set common form |
| dc.title.none.fl_str_mv | Localization of delivered AGAT and GAMT in WT fibroblasts. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>Immunofluorescence (IF) of WT fibroblasts stably expressing AGAT + GAMT and empty vector infected controls imaged at 63x magnification. N = 4. Scale bars indicate 10 µm.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_e421577e2ade63d7bb72a0a0892cbef2 |
| identifier_str_mv | 10.1371/journal.pone.0319350.g003 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/28964382 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Localization of delivered AGAT and GAMT in WT fibroblasts.Chloe Wells (17231887)Jon Sorgenfrei (21273708)Sadie L. Johnson (21273711)Devin Albertson (21273714)Jared Rutter (2128906)Steven Andrew Baker (10150952)BiochemistryMedicineCell BiologyGeneticsMolecular BiologyMental Healthtarget cell typesnatural cellular compartmenthighly energetic tissuescritical metabolite usedaffected individuals suffercreatine uptake reliescreatine transporter 1healthy control fibroblastsendogenous creatine synthesisdiv >< pintracellular creatine concentrationsintracellular synthesistransport creatineprimary fibroblastspatient fibroblastsintracellular concentrationslc6a8 </selectively expressedprotein productproper targetingphenotypes referredlinked genelike behaviorsintellectual disabilityhek293t cellsgenetic defectsgene therapygatm </function mutationsfar exceedingeffective therapiescommon setcommon form<p>Immunofluorescence (IF) of WT fibroblasts stably expressing AGAT + GAMT and empty vector infected controls imaged at 63x magnification. N = 4. Scale bars indicate 10 µm.</p>2025-05-08T17:50:44ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pone.0319350.g003https://figshare.com/articles/figure/Localization_of_delivered_AGAT_and_GAMT_in_WT_fibroblasts_/28964382CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/289643822025-05-08T17:50:44Z |
| spellingShingle | Localization of delivered AGAT and GAMT in WT fibroblasts. Chloe Wells (17231887) Biochemistry Medicine Cell Biology Genetics Molecular Biology Mental Health target cell types natural cellular compartment highly energetic tissues critical metabolite used affected individuals suffer creatine uptake relies creatine transporter 1 healthy control fibroblasts endogenous creatine synthesis div >< p intracellular creatine concentrations intracellular synthesis transport creatine primary fibroblasts patient fibroblasts intracellular concentration slc6a8 </ selectively expressed protein product proper targeting phenotypes referred linked gene like behaviors intellectual disability hek293t cells genetic defects gene therapy gatm </ function mutations far exceeding effective therapies common set common form |
| status_str | publishedVersion |
| title | Localization of delivered AGAT and GAMT in WT fibroblasts. |
| title_full | Localization of delivered AGAT and GAMT in WT fibroblasts. |
| title_fullStr | Localization of delivered AGAT and GAMT in WT fibroblasts. |
| title_full_unstemmed | Localization of delivered AGAT and GAMT in WT fibroblasts. |
| title_short | Localization of delivered AGAT and GAMT in WT fibroblasts. |
| title_sort | Localization of delivered AGAT and GAMT in WT fibroblasts. |
| topic | Biochemistry Medicine Cell Biology Genetics Molecular Biology Mental Health target cell types natural cellular compartment highly energetic tissues critical metabolite used affected individuals suffer creatine uptake relies creatine transporter 1 healthy control fibroblasts endogenous creatine synthesis div >< p intracellular creatine concentrations intracellular synthesis transport creatine primary fibroblasts patient fibroblasts intracellular concentration slc6a8 </ selectively expressed protein product proper targeting phenotypes referred linked gene like behaviors intellectual disability hek293t cells genetic defects gene therapy gatm </ function mutations far exceeding effective therapies common set common form |