Hematocrit levels.
<p><b>(a)</b> VPA-DPO animals showed a significantly greater increase in hematocrit from P21 to P28 compared to Control (<i>p =</i> 0.013, <i>d =</i> 2.26). <b>(b)</b> Hematocrit at P28 was significantly elevated in DPO compared to Control (<i...
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2025
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| _version_ | 1849927643330248704 |
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| author | Ömer Yusuf İpek (22676357) |
| author2 | Tuğba Kirboğa (22676360) Ercan Babur (22676363) Nurcan Dursun (22676366) Cem Süer (22676369) |
| author2_role | author author author author |
| author_facet | Ömer Yusuf İpek (22676357) Tuğba Kirboğa (22676360) Ercan Babur (22676363) Nurcan Dursun (22676366) Cem Süer (22676369) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ömer Yusuf İpek (22676357) Tuğba Kirboğa (22676360) Ercan Babur (22676363) Nurcan Dursun (22676366) Cem Süer (22676369) |
| dc.date.none.fl_str_mv | 2025-11-24T18:24:31Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0337294.g008 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Hematocrit_levels_/30696647 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Cell Biology Genetics Neuroscience Biotechnology Developmental Biology Science Policy Mental Health Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified pronounced hematological response five consecutive days exposed rats beginning early brain maturation disrupt neural development critical translational challenge behavioral assessments using 2 &# 8211 postnatal day 21 administered darbepoetin alfa acting epo analogue therapeutic timing limitations postnatal darbepoetin therapeutic window timing gap delayed timing valproic acid typically diagnosed though non significant improvements retain efficacy relevant social neuroprotective effects interventions effective influence neurodevelopment findings suggest environmental factors diagnostic period complex genetic cognitive behaviors chamber test 3 years |
| dc.title.none.fl_str_mv | Hematocrit levels. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p><b>(a)</b> VPA-DPO animals showed a significantly greater increase in hematocrit from P21 to P28 compared to Control (<i>p =</i> 0.013, <i>d =</i> 2.26). <b>(b)</b> Hematocrit at P28 was significantly elevated in DPO compared to Control (<i>p =</i> 0.022, <i>d =</i> 3.38). VPA-DPO was significantly higher than VPA (<i>p =</i> 0.009, <i>d =</i> 3.93). Two-way ANOVA revealed a significant main effect of DPO (<i>F =</i> 80.3, <i>p <</i> 0.0001) with no effect of VPA or VPA × DPO interaction. Individual data points shown with bars representing group means ± SEM. Statistical comparisons: (a) one-way ANOVA with Tukey’s HSD; <b>(b)</b> Kruskal-Wallis with Dunn’s post hoc and Holm-Bonferroni correction, two-way ANOVA for main effects. *p < 0.05, **p < 0.01, ***p < 0.001. Note: P21 data for the VPA group was unavailable due to equipment failure.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_e43cd4eb58472e30cae0c751cce9cc04 |
| identifier_str_mv | 10.1371/journal.pone.0337294.g008 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30696647 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Hematocrit levels.Ömer Yusuf İpek (22676357)Tuğba Kirboğa (22676360)Ercan Babur (22676363)Nurcan Dursun (22676366)Cem Süer (22676369)Cell BiologyGeneticsNeuroscienceBiotechnologyDevelopmental BiologyScience PolicyMental HealthBiological Sciences not elsewhere classifiedChemical Sciences not elsewhere classifiedpronounced hematological responsefive consecutive daysexposed rats beginningearly brain maturationdisrupt neural developmentcritical translational challengebehavioral assessments using2 &# 8211postnatal day 21administered darbepoetin alfaacting epo analoguetherapeutic timing limitationspostnatal darbepoetintherapeutic windowtiming gapdelayed timingvalproic acidtypically diagnosedthough nonsignificant improvementsretain efficacyrelevant socialneuroprotective effectsinterventions effectiveinfluence neurodevelopmentfindings suggestenvironmental factorsdiagnostic periodcomplex geneticcognitive behaviorschamber test3 years<p><b>(a)</b> VPA-DPO animals showed a significantly greater increase in hematocrit from P21 to P28 compared to Control (<i>p =</i> 0.013, <i>d =</i> 2.26). <b>(b)</b> Hematocrit at P28 was significantly elevated in DPO compared to Control (<i>p =</i> 0.022, <i>d =</i> 3.38). VPA-DPO was significantly higher than VPA (<i>p =</i> 0.009, <i>d =</i> 3.93). Two-way ANOVA revealed a significant main effect of DPO (<i>F =</i> 80.3, <i>p <</i> 0.0001) with no effect of VPA or VPA × DPO interaction. Individual data points shown with bars representing group means ± SEM. Statistical comparisons: (a) one-way ANOVA with Tukey’s HSD; <b>(b)</b> Kruskal-Wallis with Dunn’s post hoc and Holm-Bonferroni correction, two-way ANOVA for main effects. *p < 0.05, **p < 0.01, ***p < 0.001. Note: P21 data for the VPA group was unavailable due to equipment failure.</p>2025-11-24T18:24:31ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pone.0337294.g008https://figshare.com/articles/figure/Hematocrit_levels_/30696647CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/306966472025-11-24T18:24:31Z |
| spellingShingle | Hematocrit levels. Ömer Yusuf İpek (22676357) Cell Biology Genetics Neuroscience Biotechnology Developmental Biology Science Policy Mental Health Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified pronounced hematological response five consecutive days exposed rats beginning early brain maturation disrupt neural development critical translational challenge behavioral assessments using 2 &# 8211 postnatal day 21 administered darbepoetin alfa acting epo analogue therapeutic timing limitations postnatal darbepoetin therapeutic window timing gap delayed timing valproic acid typically diagnosed though non significant improvements retain efficacy relevant social neuroprotective effects interventions effective influence neurodevelopment findings suggest environmental factors diagnostic period complex genetic cognitive behaviors chamber test 3 years |
| status_str | publishedVersion |
| title | Hematocrit levels. |
| title_full | Hematocrit levels. |
| title_fullStr | Hematocrit levels. |
| title_full_unstemmed | Hematocrit levels. |
| title_short | Hematocrit levels. |
| title_sort | Hematocrit levels. |
| topic | Cell Biology Genetics Neuroscience Biotechnology Developmental Biology Science Policy Mental Health Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified pronounced hematological response five consecutive days exposed rats beginning early brain maturation disrupt neural development critical translational challenge behavioral assessments using 2 &# 8211 postnatal day 21 administered darbepoetin alfa acting epo analogue therapeutic timing limitations postnatal darbepoetin therapeutic window timing gap delayed timing valproic acid typically diagnosed though non significant improvements retain efficacy relevant social neuroprotective effects interventions effective influence neurodevelopment findings suggest environmental factors diagnostic period complex genetic cognitive behaviors chamber test 3 years |