Total Synthesis and Pharmacological Evaluation of Phochrodines A–C

The first syntheses of the Phomopsis-isolated natural products phochrodines A–C are reported. Functional group manipulations on a key 5H-chromeno[4,3-b]pyridine intermediate, itself synthesized from intramolecular Suzuki–Miyaura coupling, enab...

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Bibliographic Details
Main Author:	Jacob L. Bouchard (20980454) (author)
Other Authors:	Sichen Chang (1475053) (author), Srinivasan Krishnan (5447255) (author), Christopher C. Presley (17943949) (author), Olivier Boutaud (1340007) (author), Nathan D. Schley (1863295) (author), Darren W. Engers (655505) (author), Julie L. Engers (1475044) (author), Craig W. Lindsley (203380) (author), Aaron M. Bender (5155397) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Medicine Molecular Biology Pharmacology Biotechnology Ecology Chemical Sciences not elsewhere classified three natural products preliminary drug metabolism medicinal chemists working functional group manipulations >] pyridine intermediate – c yielding syntheses total synthesis sufficient material phomopsis </ pharmacological evaluation key 5 h </ first syntheses enabled facile b </ attractive scaffold antidepressant space >- chromeno 3 -<
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Total Synthesis and Pharmacological Evaluation of Phochrodines A–C

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