Total Synthesis of Rohitukine and Dysoline and Their Anticancer Analogues Flavopiridol and IIIM-290

Total Synthesis of Rohitukine and Dysoline and Their Anticancer Analogues Flavopiridol and IIIM-290

Rohitukine is a naturally occurring piperidine alkaloid that has led to the discovery of several potent CDK9/T1 inhibitors, including flavopiridol and IIIM-290. (−)-(3<i>S</i>,4<i>R</i>)-1-Methyl-4-(2,4,6-trimethoxyphenyl)piperidin-3-ol serves as a crucial chiral intermediate...

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Bibliographic Details
Main Author: Madhusmita Nayak (720104) (author)
Other Authors: Kailas V. Kallurkar (22066212) (author), Tejaswi Somarowthu (20414975) (author), Jagadeesh Babu Nanubolu (567973) (author), Sandip B. Bharate (22066215) (author)
Published: 2025
Subjects:
Biophysics
Biochemistry
Genetics
Molecular Biology
Pharmacology
Biotechnology
Chemical Sciences not elsewhere classified
closure equilibrium process
>- selectride without
>) diastereomer intermediate
stable regioisomer dysoline
several potent cdk9
chromatographic purification steps
4 -( 2
crucial chiral intermediate
anticancer analogues flavopiridol
chromatographic purification
chiral alcohol
≥ 99
t1 inhibitors
successfully employed
ol serves
including flavopiridol
giving thermodynamically
diastereoselective reduction
developed method
chromone nucleus
c8 position
>, 4
>)- 1
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