A summary of the U2OS dataset.

A summary of the U2OS dataset.

<p>The reason for excluding a small fraction of the cells was because they either died pre cisplatin administration, or they never divided.</p>

محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Anton Iyer (22278981) (author)
مؤلفون آخرون:	Adrian Alva (22278984) (author), Adrián E. Granada (22278987) (author), Shaon Chakrabarti (14927511) (author)
منشور في:	2025
الموضوعات:	Biophysics Cell Biology Genetics Pharmacology Biotechnology Cancer Biological Sciences not elsewhere classified without requiring knowledge underlying molecular architecture stochastic model implementing rules simultaneously recapitulates observe minor changes model also demonstrates lapse microscopy data eventual permanent resistance despite clear evidence barcode diversity change allowing multiple routes 3 cellular generations observed lineage correlations observed decay rates drug tolerant persisters fate lineage correlations persister fate decisions div >< p population dynamics arise states shape drug drug might lead persister correlations population dynamics fate map population measurements overall dynamics cell fate drug persistence drug contributions drug birth drug ancestors death rates surprising independence slower times sensitive cells results provide quantitative description proliferative nature misleading interpretations measured birth least 2 inherited across increasing levels high probability get modulated genotoxic stress faster times cycling speed conceptual framework
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