From Shallow to Full Wrapping: Geometry and Deformability Dictate Lipid Vesicle Internalization

The deformability and adhesion of vesicles critically influence their engulfment by lipid membranes, a process that is central to endocytosis, viral entry, drug delivery, and intercellular transport. We developed a versatile experimental system of giant unilamellar vesicles (GUVs) that interact via...

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Bibliographic Details
Main Author:	Stijn van der Ham (18195823) (author)
Other Authors:	Alexander Brown (2732683) (author), Halim Kusumaatmaja (1283520) (author), Hanumantha Rao Vutukuri (1552948) (author)
Published:	2025
Subjects:	Biophysics Medicine Cell Biology Genetics Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Physical Sciences not elsewhere classified vesicles critically influence versatile experimental system interact via depletion giant unilamellar vesicles fully wrapped states vesicle size exceeds deformability controls transitions suppressing full engulfment vesicle engulfment vesicle curvature viral entry tunable platform results establish membrane bending mechanical criterion lipid membranes larger ones intercellular transport induced switching full wrapping experimentally quantify exocytic engulfment drug delivery continuum simulations combining experiments
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From Shallow to Full Wrapping: Geometry and Deformability Dictate Lipid Vesicle Internalization

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