Single contraction simulation shows that ligand connectivity leads to an increase in migration efficiency.
<p>(<b>a</b>) Schematic of one-dimensional model of epithelial cells represented by springs sliding viscously over rigid ligand springs fixed to substrate springs, after self-propelling forces applied at leader nodes. Schematics showing differences in force balance among cell-ligan...
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2025
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| Summary: | <p>(<b>a</b>) Schematic of one-dimensional model of epithelial cells represented by springs sliding viscously over rigid ligand springs fixed to substrate springs, after self-propelling forces applied at leader nodes. Schematics showing differences in force balance among cell-ligand forces (<i>F</i><sub><i>c-l</i></sub>), ligand-ligand forces (<i>F</i><sub><i>l-l</i></sub>) and ligand-substrate forces (<i>F</i><sub><i>l-s</i></sub>) between connected ligand (<b>b</b>) and disconnected ligand (<b>c</b>). Forces are depicted as green arrows. Simulated kymographs of (<b>d,e</b>) velocity, (<b>f,g</b>) traction for connected (left) and disconnected (right) ligands for single contraction experiment. Plots showing velocity evolution at the leading edge for connected ligand (<b>h</b>) during the single contraction event for disconnected ligand (<b>i</b>). Plots showing traction evolution at the leading edge for connected ligand (<b>j</b>) during the single contraction event for disconnected ligand (<b>k</b>).</p> |
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