Overcoming limitations in sparse cell-type predictions for a biologically reliable task.
<p><b>A</b>, Illustration of mouse hippocampus on mouse brain coronal section. <b>B</b>, 2D UMAP representation of the 8 HPF cell types. <b>C</b>, Overlapping CA1 and CA3 due to cell type similarity, with cluster radii calculated using centroid distances and...
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2025
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| Summary: | <p><b>A</b>, Illustration of mouse hippocampus on mouse brain coronal section. <b>B</b>, 2D UMAP representation of the 8 HPF cell types. <b>C</b>, Overlapping CA1 and CA3 due to cell type similarity, with cluster radii calculated using centroid distances and cell locations at maximum distances. <b>D-I</b>, Model predictions for CA3 in the P8 and <b>J-O</b> in adult mouse brain are presented. <b>D, J</b>, In DWLS prediction, CA3 cells are slightly over-represented in mouse brain spots (blue shade), with frequent spot prediction failures (red). <b>E, K</b>, RCTD prediction reveals high percentages of cells in spots located in hippocampal, thalamic and cortical regions. <b>F, L</b>, S-DWLS prediction displays confined but still disproportionate of cells in spots concentrated in stratum oriens, stratum pyramidale and stratum lucidum and thalamus regions. <b>G, M</b>, SPOTlight predicts a high abundance of CA3 cells in DG and across various brain zones including cortex. <b>H, N</b>, Stereoscope predicts CA3 in almost all hippocampus, thalamus and cortical regions, while <b>I, O</b> WISpR predicts CA3 cells in exactly CA3 morphological region in both P8 and adult mice, supporting its more accurate prediction on mismatched datasets.</p> |
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