Data Sheet 1_Acute myeloid leukemia cells adhere to bone marrow and acquire chemoresistance by downregulating UNC5B expression.pdf
<p>Acute myeloid leukemia (AML) is a malignant tumor of the hematological system. Because of its characteristics of recurrence, refractory and chemoresistance, new therapeutic targets need to be identified. Adhesion and proliferation are characteristics of AML cells, and critical steps in indu...
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2024
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| _version_ | 1855376108842647552 |
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| author | Teng Teng (3129972) |
| author2 | Liping Ren (228832) Jilong Xiao (19729852) Zhiyu Shi (11361373) Lanbo Li (12641773) Chunhong Song (5955896) |
| author2_role | author author author author author |
| author_facet | Teng Teng (3129972) Liping Ren (228832) Jilong Xiao (19729852) Zhiyu Shi (11361373) Lanbo Li (12641773) Chunhong Song (5955896) |
| author_role | author |
| dc.creator.none.fl_str_mv | Teng Teng (3129972) Liping Ren (228832) Jilong Xiao (19729852) Zhiyu Shi (11361373) Lanbo Li (12641773) Chunhong Song (5955896) |
| dc.date.none.fl_str_mv | 2024-09-24T05:03:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fonc.2024.1394443.s001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Data_Sheet_1_Acute_myeloid_leukemia_cells_adhere_to_bone_marrow_and_acquire_chemoresistance_by_downregulating_UNC5B_expression_pdf/27093583 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Oncology and Carcinogenesis not elsewhere classified acute myeloid leukemia UNC5B adhesion proliferation chemoresistance |
| dc.title.none.fl_str_mv | Data Sheet 1_Acute myeloid leukemia cells adhere to bone marrow and acquire chemoresistance by downregulating UNC5B expression.pdf |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | <p>Acute myeloid leukemia (AML) is a malignant tumor of the hematological system. Because of its characteristics of recurrence, refractory and chemoresistance, new therapeutic targets need to be identified. Adhesion and proliferation are characteristics of AML cells, and critical steps in inducing chemotherapy resistance. In this study, we reported that UNC5B inhibits AML cell bone marrow adhesion, inhibits AML cell proliferation and increases sensitivity to chemotherapy. Mechanistically, RNA sequencing (RNA-seq) and experimental results revealed that overexpression of UNC5B inhibits adhesion and proliferation signaling pathways and inhibits the expression of MPZL1, CLDN23, IGF2 and WNT7B. In conclusion, our findings suggest that UNC5B serves as a prognostic indicator and a potential therapeutic target for AML.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_eb79e9bc2f0945644edf78f371661ba9 |
| identifier_str_mv | 10.3389/fonc.2024.1394443.s001 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/27093583 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Data Sheet 1_Acute myeloid leukemia cells adhere to bone marrow and acquire chemoresistance by downregulating UNC5B expression.pdfTeng Teng (3129972)Liping Ren (228832)Jilong Xiao (19729852)Zhiyu Shi (11361373)Lanbo Li (12641773)Chunhong Song (5955896)Oncology and Carcinogenesis not elsewhere classifiedacute myeloid leukemiaUNC5Badhesionproliferationchemoresistance<p>Acute myeloid leukemia (AML) is a malignant tumor of the hematological system. Because of its characteristics of recurrence, refractory and chemoresistance, new therapeutic targets need to be identified. Adhesion and proliferation are characteristics of AML cells, and critical steps in inducing chemotherapy resistance. In this study, we reported that UNC5B inhibits AML cell bone marrow adhesion, inhibits AML cell proliferation and increases sensitivity to chemotherapy. Mechanistically, RNA sequencing (RNA-seq) and experimental results revealed that overexpression of UNC5B inhibits adhesion and proliferation signaling pathways and inhibits the expression of MPZL1, CLDN23, IGF2 and WNT7B. In conclusion, our findings suggest that UNC5B serves as a prognostic indicator and a potential therapeutic target for AML.</p>2024-09-24T05:03:00ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.3389/fonc.2024.1394443.s001https://figshare.com/articles/dataset/Data_Sheet_1_Acute_myeloid_leukemia_cells_adhere_to_bone_marrow_and_acquire_chemoresistance_by_downregulating_UNC5B_expression_pdf/27093583CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/270935832024-09-24T05:03:00Z |
| spellingShingle | Data Sheet 1_Acute myeloid leukemia cells adhere to bone marrow and acquire chemoresistance by downregulating UNC5B expression.pdf Teng Teng (3129972) Oncology and Carcinogenesis not elsewhere classified acute myeloid leukemia UNC5B adhesion proliferation chemoresistance |
| status_str | publishedVersion |
| title | Data Sheet 1_Acute myeloid leukemia cells adhere to bone marrow and acquire chemoresistance by downregulating UNC5B expression.pdf |
| title_full | Data Sheet 1_Acute myeloid leukemia cells adhere to bone marrow and acquire chemoresistance by downregulating UNC5B expression.pdf |
| title_fullStr | Data Sheet 1_Acute myeloid leukemia cells adhere to bone marrow and acquire chemoresistance by downregulating UNC5B expression.pdf |
| title_full_unstemmed | Data Sheet 1_Acute myeloid leukemia cells adhere to bone marrow and acquire chemoresistance by downregulating UNC5B expression.pdf |
| title_short | Data Sheet 1_Acute myeloid leukemia cells adhere to bone marrow and acquire chemoresistance by downregulating UNC5B expression.pdf |
| title_sort | Data Sheet 1_Acute myeloid leukemia cells adhere to bone marrow and acquire chemoresistance by downregulating UNC5B expression.pdf |
| topic | Oncology and Carcinogenesis not elsewhere classified acute myeloid leukemia UNC5B adhesion proliferation chemoresistance |