PAMs are maintained in regions of truncal LOH and partially lost in regions of private LOH.

All data shown is from case A38. A) All truncal PAMs on chromosome 18 in all four cell lines have a VAF of 1, and B) All truncal PAMs discovered are present in all four cell lines with a copy number of 1 (haploid). C) A38 cell lines T...

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Bibliographic Details
Main Author:	Kirsten Bowland (15162758) (author)
Other Authors:	Jiaying Lai (17793078) (author), Alyza Skaist (6741407) (author), Yan Zhang (8098) (author), Selina Shiqing K. Teh (15162749) (author), Nicholas J. Roberts (2841527) (author), Elizabeth Thompson (2136988) (author), Sarah J. Wheelan (14926715) (author), Ralph H. Hruban (265335) (author), Rachel Karchin (61264) (author), Matthew H. Bailey (15147087) (author), Christine A. Iacobuzio-Donahue (213444) (author), James R. Eshleman (14989454) (author)
Published:	2024
Subjects:	Cell Biology Genetics Molecular Biology Pharmacology Biotechnology Evolutionary Biology Marine Biology Cancer Infectious Diseases year survival rates varying success rates specific &# 8220 protospacer adjacent motif people worldwide annually ngg &# 8221 current therapeutic regimens represent genetic vulnerabilities private loh ), normal aging prior form novel tumor matched primary tumor cas9 pam targets predict pam loss xlink "> regions xlink "> primary tumor pam targets novel way genetic instability bioinformatic tumor primary carcinomas universally conserved truncal loh surgical resection strongly retained related deaths regions may pancreatic adenocarcinomas pams occurring pams located normal subtraction metastatic tissue metastatic samples metastatic disease leading cause individual cells identified rules heterozygous regions genomic stability genetically targeted depth capture
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PAMs are maintained in regions of truncal LOH and partially lost in regions of private LOH.

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