Engineering of Integral Membrane Metalloenzyme UndB and Designing of a Cell-Free Biocatalytic Platform Enabled Efficient 1‑Alkene Production

The bioproduction of 1-alkenes is of significant global interest due to their potential as green commodity chemicals and next-generation ‘drop-in’ biofuels. Here, we report an engineering strategy to enhance the catalytic activity and substrate specificity of the membrane-bound metalloenzyme UndB, s...

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Bibliographic Details
Main Author:	Tabish Iqbal (5593025) (author)
Other Authors:	Subhashini Murugan (17407884) (author), Jayaprakash Karupusamy (22428500) (author), Abhishek Sirohiwal (5368541) (author), Debasis Das (1344114) (author)
Published:	2025
Subjects:	Biophysics Biochemistry Biotechnology Immunology Inorganic Chemistry Physical Sciences not elsewhere classified green commodity chemicals generation ‘ drop enabling efficient long scale simulations unveiled free biocatalytic platform chain fatty acids bound metalloenzyme undb system achieved 98 governs substrate uptake alkene yield using highly efficient undb providing mechanistic insights promising bioproduction strategy system achieved yield medium simulations revealed offering insights highly dynamic alkene production undb ’ undb family engineered undb chain 1 biocatalytic 1 ’ biofuels undecene production total turnover substrate specificity substrate recognition structural analysis significantly improving precise modulation pair network mild conditions key determinant fold improvement evolutionary adaptability engineering strategy crucial ion catalytic activity catalyst loading 04 mol
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Engineering of Integral Membrane Metalloenzyme UndB and Designing of a Cell-Free Biocatalytic Platform Enabled Efficient 1‑Alkene Production

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