Figure 1 from Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases
<p>Mutational characterization of primary colorectal cancer and CRLM. <b>A,</b> Venn diagram demonstrating primary colorectal cancer and CRLM that underwent genomic analysis. Co-Barplot illustrating most frequently mutated genes across 13 matched primary colorectal cancer and CRLM,...
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2025
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| _version_ | 1849927638486876160 |
|---|---|
| author | Colin S. Wood (15293247) |
| author2 | Kathryn A.F. Pennel (15293250) Holly Leslie (15293253) Assya Legrini (15293256) Andrew J. Cameron (15046037) Lydia Melissourgou-Syka (15293259) Jean A. Quinn (15293262) Hester C. van Wyk (15293265) Jennifer Hay (15293268) Antonia K. Roseweir (15293271) Colin Nixon (14949516) Campbell S.D. Roxburgh (15293274) Donald C. McMillan (15293277) Andrew V. Biankin (14937726) Owen J. Sansom (14949234) Paul G. Horgan (15293280) Joanne Edwards (14939606) Colin W. Steele (15293283) Nigel B. Jamieson (15046064) |
| author2_role | author author author author author author author author author author author author author author author author author author |
| author_facet | Colin S. Wood (15293247) Kathryn A.F. Pennel (15293250) Holly Leslie (15293253) Assya Legrini (15293256) Andrew J. Cameron (15046037) Lydia Melissourgou-Syka (15293259) Jean A. Quinn (15293262) Hester C. van Wyk (15293265) Jennifer Hay (15293268) Antonia K. Roseweir (15293271) Colin Nixon (14949516) Campbell S.D. Roxburgh (15293274) Donald C. McMillan (15293277) Andrew V. Biankin (14937726) Owen J. Sansom (14949234) Paul G. Horgan (15293280) Joanne Edwards (14939606) Colin W. Steele (15293283) Nigel B. Jamieson (15046064) |
| author_role | author |
| dc.creator.none.fl_str_mv | Colin S. Wood (15293247) Kathryn A.F. Pennel (15293250) Holly Leslie (15293253) Assya Legrini (15293256) Andrew J. Cameron (15046037) Lydia Melissourgou-Syka (15293259) Jean A. Quinn (15293262) Hester C. van Wyk (15293265) Jennifer Hay (15293268) Antonia K. Roseweir (15293271) Colin Nixon (14949516) Campbell S.D. Roxburgh (15293274) Donald C. McMillan (15293277) Andrew V. Biankin (14937726) Owen J. Sansom (14949234) Paul G. Horgan (15293280) Joanne Edwards (14939606) Colin W. Steele (15293283) Nigel B. Jamieson (15046064) |
| dc.date.none.fl_str_mv | 2025-11-24T23:04:58Z |
| dc.identifier.none.fl_str_mv | 10.1158/0008-5472.30700345 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Figure_1_from_Spatially_Resolved_Transcriptomics_Deconvolutes_Prognostic_Histological_Subgroups_in_Patients_with_Colorectal_Cancer_and_Synchronous_Liver_Metastases/30700345 |
| dc.rights.none.fl_str_mv | CC BY info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Cancer Tumor Biology Cancer Detection and Diagnosis Methods and Technology Biomarkers Diagnostic biomarkers Gastrointestinal Cancers Colorectal cancer Gene Technologies High-throughput sequencing Progression, Invasion & Metastasis |
| dc.title.none.fl_str_mv | Figure 1 from Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>Mutational characterization of primary colorectal cancer and CRLM. <b>A,</b> Venn diagram demonstrating primary colorectal cancer and CRLM that underwent genomic analysis. Co-Barplot illustrating most frequently mutated genes across 13 matched primary colorectal cancer and CRLM, including mutation type. Genes are ordered by mutational frequency. Sections were sequenced using GPOL (Glasgow Precision Oncology Laboratory) mutational panel. <b>B,</b> Oncoplot demonstrating concurrent mutations in the 13 matched lesions. Patients are ranked according to co-mutational burden on the <i>y</i>-axis and ranked according to KM grade on the <i>x</i>-axis. Blue, gene mutated in primary only; red, gene mutated in metastasis only; purple, mutated in primary and metastasis. The right-hand three columns denote the percentage of total patients with each mutation type. <b>C,</b> Correlation matrix demonstrating co-occurrence of mutations, with left of the blue demarcation line representing primary colorectal cancer, right of the blue demarcation line representing CRLM (pair-wise Fisher exact test; *, <i>P</i> < 0.05). Gene names are displayed along the <i>x</i>- and <i>y</i>-axes ordered by mutational frequency. Dark green boxes represent significant co-occurrence. <b>D,</b> Box plot illustrating mutational burden in primary colorectal cancer and CRLM according to KM grade using the Mann–Whitney test to assess for statistically significant difference between KM groups.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_ecae7444a7308a203f33f918b245550a |
| identifier_str_mv | 10.1158/0008-5472.30700345 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30700345 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY |
| spelling | Figure 1 from Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver MetastasesColin S. Wood (15293247)Kathryn A.F. Pennel (15293250)Holly Leslie (15293253)Assya Legrini (15293256)Andrew J. Cameron (15046037)Lydia Melissourgou-Syka (15293259)Jean A. Quinn (15293262)Hester C. van Wyk (15293265)Jennifer Hay (15293268)Antonia K. Roseweir (15293271)Colin Nixon (14949516)Campbell S.D. Roxburgh (15293274)Donald C. McMillan (15293277)Andrew V. Biankin (14937726)Owen J. Sansom (14949234)Paul G. Horgan (15293280)Joanne Edwards (14939606)Colin W. Steele (15293283)Nigel B. Jamieson (15046064)CancerTumor BiologyCancer Detection and DiagnosisMethods and TechnologyBiomarkersDiagnostic biomarkersGastrointestinal CancersColorectal cancerGene TechnologiesHigh-throughput sequencingProgression, Invasion & Metastasis<p>Mutational characterization of primary colorectal cancer and CRLM. <b>A,</b> Venn diagram demonstrating primary colorectal cancer and CRLM that underwent genomic analysis. Co-Barplot illustrating most frequently mutated genes across 13 matched primary colorectal cancer and CRLM, including mutation type. Genes are ordered by mutational frequency. Sections were sequenced using GPOL (Glasgow Precision Oncology Laboratory) mutational panel. <b>B,</b> Oncoplot demonstrating concurrent mutations in the 13 matched lesions. Patients are ranked according to co-mutational burden on the <i>y</i>-axis and ranked according to KM grade on the <i>x</i>-axis. Blue, gene mutated in primary only; red, gene mutated in metastasis only; purple, mutated in primary and metastasis. The right-hand three columns denote the percentage of total patients with each mutation type. <b>C,</b> Correlation matrix demonstrating co-occurrence of mutations, with left of the blue demarcation line representing primary colorectal cancer, right of the blue demarcation line representing CRLM (pair-wise Fisher exact test; *, <i>P</i> < 0.05). Gene names are displayed along the <i>x</i>- and <i>y</i>-axes ordered by mutational frequency. Dark green boxes represent significant co-occurrence. <b>D,</b> Box plot illustrating mutational burden in primary colorectal cancer and CRLM according to KM grade using the Mann–Whitney test to assess for statistically significant difference between KM groups.</p>2025-11-24T23:04:58ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1158/0008-5472.30700345https://figshare.com/articles/figure/Figure_1_from_Spatially_Resolved_Transcriptomics_Deconvolutes_Prognostic_Histological_Subgroups_in_Patients_with_Colorectal_Cancer_and_Synchronous_Liver_Metastases/30700345CC BYinfo:eu-repo/semantics/openAccessoai:figshare.com:article/307003452025-11-24T23:04:58Z |
| spellingShingle | Figure 1 from Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases Colin S. Wood (15293247) Cancer Tumor Biology Cancer Detection and Diagnosis Methods and Technology Biomarkers Diagnostic biomarkers Gastrointestinal Cancers Colorectal cancer Gene Technologies High-throughput sequencing Progression, Invasion & Metastasis |
| status_str | publishedVersion |
| title | Figure 1 from Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases |
| title_full | Figure 1 from Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases |
| title_fullStr | Figure 1 from Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases |
| title_full_unstemmed | Figure 1 from Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases |
| title_short | Figure 1 from Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases |
| title_sort | Figure 1 from Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases |
| topic | Cancer Tumor Biology Cancer Detection and Diagnosis Methods and Technology Biomarkers Diagnostic biomarkers Gastrointestinal Cancers Colorectal cancer Gene Technologies High-throughput sequencing Progression, Invasion & Metastasis |