Alterations of Ceramides, Acylcarnitines, GlyceroLPLs, and Amines in NSCLC Tissues

Abnormal lipid metabolism plays an important role in cancer development. In this study, nontargeted lipidomic study on 230 tissue specimens from 79 nonsmall cell lung cancer (NSCLC) patients was conducted using ultraperformance liquid chromatography-high-resolution mass spectrometry (UPLC-HRMS). Dow...

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Main Author:	Jie Zhang (64655) (author)
Other Authors:	Xiaoling Zang (1784689) (author), Peng Jiao (1490314) (author), Jiangyu Wu (2119462) (author), Wei Meng (505670) (author), Lizhen Zhao (17326211) (author), Zhihua Lv (3465971) (author)
Published:	2024
Subjects:	Biophysics Biochemistry Cell Biology Genetics Molecular Biology Neuroscience Physiology Biotechnology Cancer Chemical Sciences not elsewhere classified squamous cell carcinoma short – medium resolution mass spectrometry orthogonal partial least enhanced histamine methylation c2 – c16 230 tissue specimens significantly lower levels nontargeted lipidomic study medium – long ), lpc 20 significantly increased levels significantly decreased levels paired noncancerous tissues chain acylcarnitine c20 significantly increased significantly decreased lpc 20 noncancerous tissues chain acylcarnitine lpc p lpc 22 model based lpe p lipid panel important role hrms ). discriminant analysis cer d16 cancer development
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Alterations of Ceramides, Acylcarnitines, GlyceroLPLs, and Amines in NSCLC Tissues

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