N‑[(Thiophen-3-yl)methyl]benzamides as Fusion Inhibitors of Influenza Virus Targeting H1 and H5 Hemagglutinins

Novel antiviral drugs are needed to prepare for infections from influenza A virus (IAV). Here, a series of N-[(thiophen-3-yl)methyl]benzamides, which target the hemagglutinin (HA)-mediated fusion process, is reported. The most active compound, VF-57a, displays a...

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Bibliografiske detaljer
Hovedforfatter:	Silke Rimaux (22146245) (author)
Andre forfattere:	Aitor Valdivia (17707584) (author), Juan Martín-López (22146248) (author), Valeria Francesconi (12063493) (author), Celia Escriche (20707359) (author), Cato Mestdagh (20707347) (author), Ria Van Berwaer (10686932) (author), Lieselotte Schurmans (22146251) (author), Kaat Verleye (22146254) (author), Samuel Noppen (17768391) (author), Óscar Lozano (22146257) (author), Annelies Stevaert (1665184) (author), F. Javier Luque (60532) (author), Lieve Naesens (333606) (author), Santiago Vázquez (1326258) (author)
Udgivet:	2025
Fag:	Biochemistry Medicine Pharmacology Cancer Infectious Diseases Plant Biology Virology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified surface plasmon resonance resistance studies suggested molecular modeling highlighted antiviral selectivity index h5n1 pseudovirus entry ha protein refolding 57a </ b iav fusion inhibitors 50 </ sub fusion inhibitors n </ iav ). h5n1 viruses strong inhibitor respectively ). findings support expressing cells effective concentration dimethylthiophene moiety conformational change cells infected binding cavity based tether based assessment active compound acidic ph >‑[( thiophen >-[( thiophen 8 μm
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<i>N</i>‑[(Thiophen-3-yl)methyl]benzamides as Fusion Inhibitors of Influenza Virus Targeting H1 and H5 Hemagglutinins

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