A. The boxplot displays the distribution of enrichment scores for disease-related immune functions between the control group and the experimental group.
<p>The horizontal axis represents the immune-related functions, while the vertical axis indicates the enrichment score. Green and red colors are used to distinguish the control group and the experimental group, respectively. Significant differences are marked with *** (p < 0.001), ** (p <...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , |
| منشور في: |
2025
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1852022146117664768 |
|---|---|
| author | Min-xiao Wang (20868922) |
| author2 | Chang-sheng Liao (18591969) Xue-qin Wei (20868925) Yu-qin Xie (20868928) Peng-fei Han (694841) Yan-hui Yu (20868931) |
| author2_role | author author author author author |
| author_facet | Min-xiao Wang (20868922) Chang-sheng Liao (18591969) Xue-qin Wei (20868925) Yu-qin Xie (20868928) Peng-fei Han (694841) Yan-hui Yu (20868931) |
| author_role | author |
| dc.creator.none.fl_str_mv | Min-xiao Wang (20868922) Chang-sheng Liao (18591969) Xue-qin Wei (20868925) Yu-qin Xie (20868928) Peng-fei Han (694841) Yan-hui Yu (20868931) |
| dc.date.none.fl_str_mv | 2025-03-12T17:36:53Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0315408.g013 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/A_The_boxplot_displays_the_distribution_of_enrichment_scores_for_disease-related_immune_functions_between_the_control_group_and_the_experimental_group_/28584766 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Cell Biology Genetics Molecular Biology Marine Biology Infectious Diseases Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified targeted interventions directed svm )&# 8212 support vector machine may also guide hematopoietic stem cells exploring therapeutic strategies downloaded three datasets core predictive models provide new insights revealed significant differences results independently using ensure data consistency differentially expressed genes provide novel insights xlink "> initially study sheds light performed differential analysis enhance prediction accuracy clinical treatment strategies two key genes key pathogenic genes differential gene expression xlink "> key genes significant changes prediction results novel perspective gene groups data preprocessing expression levels expression analysis identify genes genes associated findings provide validation set ultimate goal training sets training set thereby integrating study aims robust list random forest pathological process particular focus notably downregulated myelodysplastic syndromes mechanisms underlying lasso regression gse19429 dataset figure illustrates enrichment analysis effective treatments disease initiation disease features disease diagnosis disease characteristics depth analysis delve deeper control group comprehensive evaluation combat algorithm bioinformatics analysis analysis workflow |
| dc.title.none.fl_str_mv | A. The boxplot displays the distribution of enrichment scores for disease-related immune functions between the control group and the experimental group. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>The horizontal axis represents the immune-related functions, while the vertical axis indicates the enrichment score. Green and red colors are used to distinguish the control group and the experimental group, respectively. Significant differences are marked with *** (p < 0.001), ** (p < 0.01), and * (p < 0.05), indicating varying degrees of statistical significance. <b>B-C</b>. bubble chart illustrating the correlation between IRF4 and ELANE genes with various immune cell types. The vertical axis represents immune cell types, while the horizontal axis depicts the Pearson correlation coefficient, with positive values indicating positive regulation and negative values indicating negative regulation. significant correlations (P < 0.05) are highlighted in red font.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_ed4cf66ec07f77ad887a82f2bc616cdf |
| identifier_str_mv | 10.1371/journal.pone.0315408.g013 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/28584766 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | A. The boxplot displays the distribution of enrichment scores for disease-related immune functions between the control group and the experimental group.Min-xiao Wang (20868922)Chang-sheng Liao (18591969)Xue-qin Wei (20868925)Yu-qin Xie (20868928)Peng-fei Han (694841)Yan-hui Yu (20868931)Cell BiologyGeneticsMolecular BiologyMarine BiologyInfectious DiseasesBiological Sciences not elsewhere classifiedMathematical Sciences not elsewhere classifiedtargeted interventions directedsvm )&# 8212support vector machinemay also guidehematopoietic stem cellsexploring therapeutic strategiesdownloaded three datasetscore predictive modelsprovide new insightsrevealed significant differencesresults independently usingensure data consistencydifferentially expressed genesprovide novel insightsxlink "> initiallystudy sheds lightperformed differential analysisenhance prediction accuracyclinical treatment strategiestwo key geneskey pathogenic genesdifferential gene expressionxlink ">key genessignificant changesprediction resultsnovel perspectivegene groupsdata preprocessingexpression levelsexpression analysisidentify genesgenes associatedfindings providevalidation setultimate goaltraining setstraining setthereby integratingstudy aimsrobust listrandom forestpathological processparticular focusnotably downregulatedmyelodysplastic syndromesmechanisms underlyinglasso regressiongse19429 datasetfigure illustratesenrichment analysiseffective treatmentsdisease initiationdisease featuresdisease diagnosisdisease characteristicsdepth analysisdelve deepercontrol groupcomprehensive evaluationcombat algorithmbioinformatics analysisanalysis workflow<p>The horizontal axis represents the immune-related functions, while the vertical axis indicates the enrichment score. Green and red colors are used to distinguish the control group and the experimental group, respectively. Significant differences are marked with *** (p < 0.001), ** (p < 0.01), and * (p < 0.05), indicating varying degrees of statistical significance. <b>B-C</b>. bubble chart illustrating the correlation between IRF4 and ELANE genes with various immune cell types. The vertical axis represents immune cell types, while the horizontal axis depicts the Pearson correlation coefficient, with positive values indicating positive regulation and negative values indicating negative regulation. significant correlations (P < 0.05) are highlighted in red font.</p>2025-03-12T17:36:53ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pone.0315408.g013https://figshare.com/articles/figure/A_The_boxplot_displays_the_distribution_of_enrichment_scores_for_disease-related_immune_functions_between_the_control_group_and_the_experimental_group_/28584766CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/285847662025-03-12T17:36:53Z |
| spellingShingle | A. The boxplot displays the distribution of enrichment scores for disease-related immune functions between the control group and the experimental group. Min-xiao Wang (20868922) Cell Biology Genetics Molecular Biology Marine Biology Infectious Diseases Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified targeted interventions directed svm )&# 8212 support vector machine may also guide hematopoietic stem cells exploring therapeutic strategies downloaded three datasets core predictive models provide new insights revealed significant differences results independently using ensure data consistency differentially expressed genes provide novel insights xlink "> initially study sheds light performed differential analysis enhance prediction accuracy clinical treatment strategies two key genes key pathogenic genes differential gene expression xlink "> key genes significant changes prediction results novel perspective gene groups data preprocessing expression levels expression analysis identify genes genes associated findings provide validation set ultimate goal training sets training set thereby integrating study aims robust list random forest pathological process particular focus notably downregulated myelodysplastic syndromes mechanisms underlying lasso regression gse19429 dataset figure illustrates enrichment analysis effective treatments disease initiation disease features disease diagnosis disease characteristics depth analysis delve deeper control group comprehensive evaluation combat algorithm bioinformatics analysis analysis workflow |
| status_str | publishedVersion |
| title | A. The boxplot displays the distribution of enrichment scores for disease-related immune functions between the control group and the experimental group. |
| title_full | A. The boxplot displays the distribution of enrichment scores for disease-related immune functions between the control group and the experimental group. |
| title_fullStr | A. The boxplot displays the distribution of enrichment scores for disease-related immune functions between the control group and the experimental group. |
| title_full_unstemmed | A. The boxplot displays the distribution of enrichment scores for disease-related immune functions between the control group and the experimental group. |
| title_short | A. The boxplot displays the distribution of enrichment scores for disease-related immune functions between the control group and the experimental group. |
| title_sort | A. The boxplot displays the distribution of enrichment scores for disease-related immune functions between the control group and the experimental group. |
| topic | Cell Biology Genetics Molecular Biology Marine Biology Infectious Diseases Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified targeted interventions directed svm )&# 8212 support vector machine may also guide hematopoietic stem cells exploring therapeutic strategies downloaded three datasets core predictive models provide new insights revealed significant differences results independently using ensure data consistency differentially expressed genes provide novel insights xlink "> initially study sheds light performed differential analysis enhance prediction accuracy clinical treatment strategies two key genes key pathogenic genes differential gene expression xlink "> key genes significant changes prediction results novel perspective gene groups data preprocessing expression levels expression analysis identify genes genes associated findings provide validation set ultimate goal training sets training set thereby integrating study aims robust list random forest pathological process particular focus notably downregulated myelodysplastic syndromes mechanisms underlying lasso regression gse19429 dataset figure illustrates enrichment analysis effective treatments disease initiation disease features disease diagnosis disease characteristics depth analysis delve deeper control group comprehensive evaluation combat algorithm bioinformatics analysis analysis workflow |