Differential Ferroportin (green) localization in LD-S and LD-R 24 hrs pi.

Differential Ferroportin (green) localization in LD-S and LD-R 24 hrs pi.

<p>Videography (20 frames/sec) showing Ferroportin localized around macrophage surface in LD-S 4hrs pi (left panel) while it surrounds LD (small blue dot represents LD nucleus) in LD-R 4 hrs pi.</p> <p>(PPTX)</p>

محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Souradeepa Ghosh (14276657) (author)
مؤلفون آخرون:	Krishna Vamshi Chigicherla (20649145) (author), Shirin Dasgupta (20649148) (author), Yasuyuki Goto (22965) (author), Budhaditya Mukherjee (106862) (author)
منشور في:	2025
الموضوعات:	Biochemistry Medicine Microbiology Cell Biology Biotechnology Evolutionary Biology Ecology Inorganic Chemistry Hematology Infectious Diseases Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified unresponsiveness points towards treating visceral leishmaniasis sustaining heightened levels selectively reshuffling macrophage recent clinical isolates leishmania donovani </ inherent metabolic shift even though anti div >< p surface iron exporter subsequent iron insufficiency higher iron utilization triggering oxidative outburst gained increased potential withstand elevated ros elevated ros levels pv thereby gaining pentavalent antimonials relies surplus iron iron within oxidative stress increased erythrophagocytosis two proteases survival edge surprising strategy study highlights sensitive counterparts parasitophorous vacuoles leishmanial activity intracellular pathogens infected macrophages genetic adaptation evolutionary persistence complex interplay cd47 surveillance aggressive proliferation
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مواد مشابهة

Localization of Ferroportin and CD71 around LD-S and LD-R PV entailing the iron flux (A.i.)
حسب: Souradeepa Ghosh (14276657)
منشور في: (2025)

Representative scheme of the downstream signaling upon LD-S vs LD-R infection at 4 hrs and 24 hrs pi.
حسب: Souradeepa Ghosh (14276657)
منشور في: (2025)

Differential Furin (red) localization with regard to ADAM10 (magenta) in LD-S and LD-R 24 hrs pi.
حسب: Souradeepa Ghosh (14276657)
منشور في: (2025)

Reshuffling of Ferroportin and NRAMP1 around LD-R-PV acts as a strategy to rapidly scavenge iron.
حسب: Souradeepa Ghosh (14276657)
منشور في: (2025)

Schematic representation of Ferrozine-based iron quantification of PV and cytoplasmic fraction and transcriptomic landscape of LD-S and LD-R-infected-MФs at 4 hrs and 24 hrs pi as compared to uninfected-MФs.
حسب: Souradeepa Ghosh (14276657)
منشور في: (2025)

Excel sheet related to S2B.ii Fig showing differential expression of M1 and M2 gene clusters in different experimental conditions (LD-S and LD-R at 4 hrs and 24 hrs pi) from RNAseq analysis.
حسب: Souradeepa Ghosh (14276657)
منشور في: (2025)

Augmented erythrophagocytosis in LD-R-infected-MФs at 24 hrs pi in concomitance with SIRP α degradation.
حسب: Souradeepa Ghosh (14276657)
منشور في: (2025)

Increased proliferation rate of LD-R-RFP compared to LD-S-GFP.
حسب: Souradeepa Ghosh (14276657)
منشور في: (2025)

LD-R outcompetes LD-S both in <i>in-vitro</i> and <i>in-vivo</i> infection: Representative flow cytometer images (BD LSRFortessa Cell Analyzer) showing the % of metacyclics and procyclic LD-promastigote population in the culture of
حسب: Souradeepa Ghosh (14276657)
منشور في: (2025)

LD-R proliferates more in high ROS by upregulating HO-1 activity.
حسب: Souradeepa Ghosh (14276657)
منشور في: (2025)

BALB/c mouse infected with LD-R for 24 weeks shows traits of severe anemia.
حسب: Souradeepa Ghosh (14276657)
منشور في: (2025)

An inherent metabolic shift in LD-R helps these parasites neutralize host-generated ROS outbursts.
حسب: Souradeepa Ghosh (14276657)
منشور في: (2025)

Low iron in the cytoplasm in LD-R-infected-MФs promotes p62/SQSTM1 mediated non-canonically activation of NRF2 (A.i.a.)
حسب: Souradeepa Ghosh (14276657)
منشور في: (2025)

Table showing EC<sub>50</sub> value against SbV as determined from the dose-response curve (S1D Fig).
حسب: Souradeepa Ghosh (14276657)
منشور في: (2025)

Low iron activates Furin which sheds to cleave the prodomain of ADAM10 rendering it activated.
حسب: Souradeepa Ghosh (14276657)
منشور في: (2025)

Excel sheet related to data points used to generate the graphs related to this manuscript.
حسب: Souradeepa Ghosh (14276657)
منشور في: (2025)

Antimony-resistant phenotype coincides with higher parasite burden if metacyclogenesis is kept as a constant factor
حسب: Souradeepa Ghosh (14276657)
منشور في: (2025)

Data Sheet 2_Disrupted macrophage autophagy as a driver of cell death and LPS-induced lethal shock in systemic inflammation.pdf
حسب: Tarek Chekroune (22481191)
منشور في: (2025)

Data Sheet 1_Disrupted macrophage autophagy as a driver of cell death and LPS-induced lethal shock in systemic inflammation.pdf
حسب: Tarek Chekroune (22481191)
منشور في: (2025)

Data Sheet 4_Disrupted macrophage autophagy as a driver of cell death and LPS-induced lethal shock in systemic inflammation.pdf
حسب: Tarek Chekroune (22481191)
منشور في: (2025)

Data Sheet 3_Disrupted macrophage autophagy as a driver of cell death and LPS-induced lethal shock in systemic inflammation.pdf
حسب: Tarek Chekroune (22481191)
منشور في: (2025)

Data Sheet 5_Disrupted macrophage autophagy as a driver of cell death and LPS-induced lethal shock in systemic inflammation.pdf
حسب: Tarek Chekroune (22481191)
منشور في: (2025)

Data Sheet 6_Disrupted macrophage autophagy as a driver of cell death and LPS-induced lethal shock in systemic inflammation.pdf
حسب: Tarek Chekroune (22481191)
منشور في: (2025)

Data Sheet 7_Disrupted macrophage autophagy as a driver of cell death and LPS-induced lethal shock in systemic inflammation.pdf
حسب: Tarek Chekroune (22481191)
منشور في: (2025)

Data Sheet 8_Disrupted macrophage autophagy as a driver of cell death and LPS-induced lethal shock in systemic inflammation.pdf
حسب: Tarek Chekroune (22481191)
منشور في: (2025)

Data Sheet 10_Disrupted macrophage autophagy as a driver of cell death and LPS-induced lethal shock in systemic inflammation.pdf
حسب: Tarek Chekroune (22481191)
منشور في: (2025)

Data Sheet 9_Disrupted macrophage autophagy as a driver of cell death and LPS-induced lethal shock in systemic inflammation.pdf
حسب: Tarek Chekroune (22481191)
منشور في: (2025)

Data Sheet 11_Disrupted macrophage autophagy as a driver of cell death and LPS-induced lethal shock in systemic inflammation.pdf
حسب: Tarek Chekroune (22481191)
منشور في: (2025)

MM.13.LD
حسب: Lydia Wooldridge (13246889)
منشور في: (2025)

Total phenolic content (TPC) and total flavonoid content (TFC) in ginger extract obtained from conventional maceration and pulsed electric field extraction.
حسب: Hataichanok Chuljerm (19144293)
منشور في: (2025)

The levels of non-heme iron in thalassemia red blood cell membrane treated with 6-shogaol-rich ginger extract at concentrations of 50, 100, and 200 µg/mL.
حسب: Hataichanok Chuljerm (19144293)
منشور في: (2025)

The levels of TBARS product in thalassemia red blood cells treated with 6-shogaol-rich ginger extract at concentrations of 50, 100, and 200 µg/mL and ascorbic acid (AA) at concentration 100 µg/mL.
حسب: Hataichanok Chuljerm (19144293)
منشور في: (2025)

Percentage inhibition of hemolysis by 6-shogaol-rich ginger extract (0–200 µg/mL) and ascorbic acid (AA; 100 µg/mL) in red blood cells obtained from thalassemia patients (A) and healthy individuals (B).
حسب: Hataichanok Chuljerm (19144293)
منشور في: (2025)

Susceptibility of thalassemic and healthy RBCs to hemolysis (A) and the anti-hemolytic activity of 6-shogaol-rich ginger extract (0–200 µg/mL) compared to ascorbic acid (AA; 100 µg/mL) in thalassemic (B) and healthy RBCs (C).
حسب: Hataichanok Chuljerm (19144293)
منشور في: (2025)

The percentage of DPPH<sup>•</sup> (A) and ABTS<sup>•+</sup> (B) inhibition of 6-shogaol-rich ginger extract and Trolox.
حسب: Hataichanok Chuljerm (19144293)
منشور في: (2025)

The concentration of 6-gingerol (A) and 6-shogaol (B) in the ginger extract obtained from conventional maceration and pulsed electric field (PEF) extraction.
حسب: Hataichanok Chuljerm (19144293)
منشور في: (2025)

HPLC chromatogram of standard 6-gingerol (0.2 mg/mL) (a), 6-shogaol (0.2 mg/mL) (b), ginger extract obtained by conventional maceration (c), and ginger extract obtained by pulsed electric field extraction (d).
حسب: Hataichanok Chuljerm (19144293)
منشور في: (2025)

Graphical abstract_6-Shogaol ginger.
حسب: Hataichanok Chuljerm (19144293)
منشور في: (2025)

Iron Modulates the Growth and Activity of Nitrate-Dependent Methanotrophic Bacteria by Reprogramming Carbon Metabolism
حسب: Xiangwu Yao (21211332)
منشور في: (2025)

Iron Modulates the Growth and Activity of Nitrate-Dependent Methanotrophic Bacteria by Reprogramming Carbon Metabolism
حسب: Xiangwu Yao (21211332)
منشور في: (2025)

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