Supplementary file 1_Global burden of ischemic heart disease due to omega-3 deficiency: 204-country analysis, 1990–2021.docx

Aim<p>This study evaluates the global burden, trends, and dietary risk factors of ischemic heart disease (IHD) from 1990 to 2021, focusing on socioeconomic and demographic variations.</p>Methods<p>The study analyzed IHD-related disability-adjusted life years (DALYs), age-standardiz...

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Päätekijä: Xiaozhi Chen (16638990) (author)
Muut tekijät: Lei Chen (54296) (author), Xinyue Yang (629144) (author), Zhiqiang Zhang (1522858) (author)
Julkaistu: 2025
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Yhteenveto:Aim<p>This study evaluates the global burden, trends, and dietary risk factors of ischemic heart disease (IHD) from 1990 to 2021, focusing on socioeconomic and demographic variations.</p>Methods<p>The study analyzed IHD-related disability-adjusted life years (DALYs), age-standardized rates (ASR), age-standardized mortality rates (ASMR), and fatality counts. Temporal trends were assessed using estimated annual percentage changes (EAPCs). Dietary risk factors, such as seafood omega-3 fatty acid deficiency, were evaluated in relation to the socio-demographic index (SDI).</p>Results<p>From 1990 to 2021, DALY rates and fatalities from IHD increased globally. Omega-3 fatty acid deficiencies were identified as a significant contributor. ASMR and age-standardized death rates (ASDR) rose most notably in Central Asia and Eastern Europe. Countries with lower SDI levels faced a higher IHD burden. National trends varied, with adverse correlations between IHD burden and SDI primarily linked to dietary risks.</p>Conclusion<p>Deficiencies in omega-3 fatty acids and other dietary risks are key factors driving global IHD patterns. Public health strategies to improve diet, particularly in low- and middle-SDI regions, are essential to reducing the IHD burden.</p>