RNA-seq analysis of fluconazole-induced genes in wild-type and upc2AΔ strains.

A. Venn diagrams illustrating the union of genes that are at least two fold-induced in wild-type cells treated with FLC (50 μg/ml) compared to untreated (2X Induced WTF), two fold-induced isogenic upc2AΔ cells treated with FLC compared to untreated upc2AΔ</i&g...

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Bibliographic Details
Main Author:	Bao Gia Vu (11507192) (author)
Other Authors:	Mark A. Stamnes (11507195) (author), Yu Li (183836) (author), P. David Rogers (11507198) (author), W. Scott Moye-Rowley (3615197) (author)
Published:	2021
Subjects:	Biochemistry Microbiology Cell Biology Genetics Molecular Biology Pharmacology Cancer Hematology Infectious Diseases Plant Biology Virology Computational Biology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified two regulatory networks translational apparatus along transcriptomic analyses revealed div >< p transcription factor called commonly acquires resistance also modulates resistance type upc2a binding called g898d upc2a saccharomyces cerevisiae </ upc2a transcription factor normal azole resistance previously described hyperactive hyperactive mutant form ergosterol biosynthetic pathway pdr1 transcription factor genes encoding components candida glabrata </ regulated membrane protein upc2a factor azole resistance glabrata </ candida </ similar form mutant forms membrane proteins upc2a impacts gene encoding encoding genes azole compounds upc2 </ pdr1 </ erg </ c </ using genome target genes studies provide strongly induced specific sterol scale approaches provide evidence pathogenic yeast often targets new perspective mutations lead mutation found master regulator large group important role high degree global regulator genes bound drug treatment cdr1 system
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RNA-seq analysis of fluconazole-induced genes in wild-type and <i>upc2AΔ</i> strains.

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