Brains with microglial IKK KO have increased GFAP expression and activated astrocytes during prion infection.

Brains with microglial IKK KO have increased GFAP expression and activated astrocytes during prion infection.

<p>Terminal mice with IKK KO microglia were compared to wpi-matched WT infected mice. <b>A</b> Brains were stained for GFAP+ astrocytes, which were counted and compared in the <b>B</b> cortex, <b>C</b> hippocampus, <b>D</b> thalamus and <b>...

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Hlavní autor:	Arielle J. D. Hay (15456341) (author)
Další autoři:	Katriana A. Popichak (12093647) (author), Genova Mumford (15456344) (author), Jifeng Bian (354060) (author), Payton Shirley (21568259) (author), Lauren Wolfrath (21568262) (author), Michael Eggers (21568265) (author), Eric M. Nicholson (8262054) (author), Ronald B. Tjalkens (3281031) (author), Mark D. Zabel (15456359) (author), Julie A. Moreno (7647266) (author)
Vydáno:	2025
Témata:	Medicine Microbiology Cell Biology Genetics Molecular Biology Neuroscience Physiology Immunology Cancer Infectious Diseases iκb kinase complex cellular stress signals irreversible neuronal loss associated behavioral deficits sc </ sup prion disease pathogenesis prion disease early div >< p cellular prion protein inflammatory signaling molecules infected brain homogenates terminal wt mice induced glial inflammation accelerated disease terminal animals protein homeostasis inflammatory cytokines induced transcription accelerated loss prion diseases signaling pathway intracranially infected infected wild infected brain b signaling specific pathology significantly lower significantly increased significantly downregulated poorly understood nuclear factor near ablation microglial survival key regulator kappa b infectious form increased density including pro host protection hippocampal neurons glial cells forms aggregates findings present cell survival associated genes
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