Crossing Barriers<i>: In Vitro</i> Cancer Model for Studying Monocyte Migration across Endothelial Barriers

Monocytes originate in the bone marrow and make up 2–10% of all white blood cells, circulating in the blood to damaged tissue and disease sites, where they differentiate into macrophages or dendritic cells. In solid tumors such as glioblastoma, monocytes recruited from the blood to the tumor site di...

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Autore principale:	Mandeep K. Marway (21734690) (author)
Altri autori:	Dickyi Bhagentsang (21734693) (author), Chitra Venugopal (3416231) (author), Sheila K. Singh (12046716) (author), Ryan G. Wylie (1510906) (author), Boyang Zhang (161507) (author)
Pubblicazione:	2025
Soggetti:	Biochemistry Medicine Cell Biology Molecular Biology Biotechnology Immunology Developmental Biology Cancer connecting three wells chip device created monocyte chemoattractant protein secretion levels increased levels remained unchanged elucidating transendothelial migration well plate modified throughput screening capabilities promoted monocyte migration controlling monocyte migration 2 – 10 csf ), interleukin model monocyte migration functional ec barrier ec barrier plays white blood cells 1 monocyte migration model interstitial flow tumor site differentiate 6 ), interleukin interstitial flow levels decreased ec barrier throughput organ tams ), easily modified dendritic cells 10 ), barrier within barrier slowed monocyte activation cancer model vivo </ vitro </ vessel wall tumor progression tissue type stimulating factor solid tumors single channel simple design inflammatory cytokines hydrogel surface fibrin hydrogel endothelial cell embedded within disease sites damaged tissue crossing barriers cancer prognosis
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Crossing Barriers<i>: In Vitro</i> Cancer Model for Studying Monocyte Migration across Endothelial Barriers

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