Crossing Barriers<i>: In Vitro</i> Cancer Model for Studying Monocyte Migration across Endothelial Barriers

Crossing Barriers<i>: In Vitro</i> Cancer Model for Studying Monocyte Migration across Endothelial Barriers

Monocytes originate in the bone marrow and make up 2–10% of all white blood cells, circulating in the blood to damaged tissue and disease sites, where they differentiate into macrophages or dendritic cells. In solid tumors such as glioblastoma, monocytes recruited from the blood to the tumor site di...

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Bibliographic Details
Main Author: Mandeep K. Marway (21734690) (author)
Other Authors: Dickyi Bhagentsang (21734693) (author), Chitra Venugopal (3416231) (author), Sheila K. Singh (12046716) (author), Ryan G. Wylie (1510906) (author), Boyang Zhang (161507) (author)
Published: 2025
Subjects:
Biochemistry
Medicine
Cell Biology
Molecular Biology
Biotechnology
Immunology
Developmental Biology
Cancer
connecting three wells
chip device created
monocyte chemoattractant protein
secretion levels increased
levels remained unchanged
elucidating transendothelial migration
well plate modified
throughput screening capabilities
promoted monocyte migration
controlling monocyte migration
2 – 10
csf ), interleukin
model monocyte migration
functional ec barrier
ec barrier plays
white blood cells
1 monocyte migration
model interstitial flow
tumor site differentiate
6 ), interleukin
interstitial flow
levels decreased
ec barrier
throughput organ
tams ),
easily modified
dendritic cells
10 ),
barrier within
barrier slowed
monocyte activation
cancer model
vivo </
vitro </
vessel wall
tumor progression
tissue type
stimulating factor
solid tumors
single channel
simple design
inflammatory cytokines
hydrogel surface
fibrin hydrogel
endothelial cell
embedded within
disease sites
damaged tissue
crossing barriers
cancer prognosis
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