Linkage-disequilibrium (LD) for variants that were polymorphic across 500 data sets with 350 case-trios.
<p>The symbol ‘+’ before variant names denote detected associated rare variants; ‘-’ denotes detected non-associated variants; ‘<’ denotes never detected associated variants. V16613 from region 5, and V37318 from region 10 display a high false positive rate, potentially due to LD. They both...
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2024
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| _version_ | 1852024720758669312 |
|---|---|
| author | Duo Yu (4243240) |
| author2 | Matthew Koslovsky (20384073) Margaret C. Steiner (13844003) Kusha Mohammadi (20384076) Chenguang Zhang (457185) Michael D. Swartz (10139250) |
| author2_role | author author author author author |
| author_facet | Duo Yu (4243240) Matthew Koslovsky (20384073) Margaret C. Steiner (13844003) Kusha Mohammadi (20384076) Chenguang Zhang (457185) Michael D. Swartz (10139250) |
| author_role | author |
| dc.creator.none.fl_str_mv | Duo Yu (4243240) Matthew Koslovsky (20384073) Margaret C. Steiner (13844003) Kusha Mohammadi (20384076) Chenguang Zhang (457185) Michael D. Swartz (10139250) |
| dc.date.none.fl_str_mv | 2024-12-04T18:33:08Z |
| dc.identifier.none.fl_str_mv | 10.1371/journal.pone.0314502.g005 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Linkage-disequilibrium_LD_for_variants_that_were_polymorphic_across_500_data_sets_with_350_case-trios_/27962574 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biochemistry Genetics Molecular Biology Evolutionary Biology Sociology Plant Biology Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified transmission disequilibrium test false positive rates burden association tests use pedigree data simultaneously detect common 30 %, respectively trio_rvemvs performed competitively individual variants level rare variants may individual rare variants trio_rvemvs outperformed pedgene common variants rare variants real data 20 %, region level level kernel applying trio_rvemvs xlink "> variant extensions trio rvemvs paper proposes outperformed rv orofacial clefts functionally related complex diseases commonly reported bayesian framework average true available samples 74 %. 500 trios 350 trios 350 families 22 associated 1500 families |
| dc.title.none.fl_str_mv | Linkage-disequilibrium (LD) for variants that were polymorphic across 500 data sets with 350 case-trios. |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | <p>The symbol ‘+’ before variant names denote detected associated rare variants; ‘-’ denotes detected non-associated variants; ‘<’ denotes never detected associated variants. V16613 from region 5, and V37318 from region 10 display a high false positive rate, potentially due to LD. They both have strong LD with all the causal rare variants that are polymorphic across 500 data sets.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_f19d4cffda9500a7eae2efd1d698e44b |
| identifier_str_mv | 10.1371/journal.pone.0314502.g005 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/27962574 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Linkage-disequilibrium (LD) for variants that were polymorphic across 500 data sets with 350 case-trios.Duo Yu (4243240)Matthew Koslovsky (20384073)Margaret C. Steiner (13844003)Kusha Mohammadi (20384076)Chenguang Zhang (457185)Michael D. Swartz (10139250)BiochemistryGeneticsMolecular BiologyEvolutionary BiologySociologyPlant BiologyBiological Sciences not elsewhere classifiedMathematical Sciences not elsewhere classifiedtransmission disequilibrium testfalse positive ratesburden association testsuse pedigree datasimultaneously detect common30 %, respectivelytrio_rvemvs performed competitivelyindividual variants levelrare variants mayindividual rare variantstrio_rvemvs outperformed pedgenecommon variantsrare variantsreal data20 %,region levellevel kernelapplying trio_rvemvsxlink ">variant extensionstrio rvemvspaper proposesoutperformed rvorofacial cleftsfunctionally relatedcomplex diseasescommonly reportedbayesian frameworkaverage trueavailable samples74 %.500 trios350 trios350 families22 associated1500 families<p>The symbol ‘+’ before variant names denote detected associated rare variants; ‘-’ denotes detected non-associated variants; ‘<’ denotes never detected associated variants. V16613 from region 5, and V37318 from region 10 display a high false positive rate, potentially due to LD. They both have strong LD with all the causal rare variants that are polymorphic across 500 data sets.</p>2024-12-04T18:33:08ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1371/journal.pone.0314502.g005https://figshare.com/articles/figure/Linkage-disequilibrium_LD_for_variants_that_were_polymorphic_across_500_data_sets_with_350_case-trios_/27962574CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/279625742024-12-04T18:33:08Z |
| spellingShingle | Linkage-disequilibrium (LD) for variants that were polymorphic across 500 data sets with 350 case-trios. Duo Yu (4243240) Biochemistry Genetics Molecular Biology Evolutionary Biology Sociology Plant Biology Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified transmission disequilibrium test false positive rates burden association tests use pedigree data simultaneously detect common 30 %, respectively trio_rvemvs performed competitively individual variants level rare variants may individual rare variants trio_rvemvs outperformed pedgene common variants rare variants real data 20 %, region level level kernel applying trio_rvemvs xlink "> variant extensions trio rvemvs paper proposes outperformed rv orofacial clefts functionally related complex diseases commonly reported bayesian framework average true available samples 74 %. 500 trios 350 trios 350 families 22 associated 1500 families |
| status_str | publishedVersion |
| title | Linkage-disequilibrium (LD) for variants that were polymorphic across 500 data sets with 350 case-trios. |
| title_full | Linkage-disequilibrium (LD) for variants that were polymorphic across 500 data sets with 350 case-trios. |
| title_fullStr | Linkage-disequilibrium (LD) for variants that were polymorphic across 500 data sets with 350 case-trios. |
| title_full_unstemmed | Linkage-disequilibrium (LD) for variants that were polymorphic across 500 data sets with 350 case-trios. |
| title_short | Linkage-disequilibrium (LD) for variants that were polymorphic across 500 data sets with 350 case-trios. |
| title_sort | Linkage-disequilibrium (LD) for variants that were polymorphic across 500 data sets with 350 case-trios. |
| topic | Biochemistry Genetics Molecular Biology Evolutionary Biology Sociology Plant Biology Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified transmission disequilibrium test false positive rates burden association tests use pedigree data simultaneously detect common 30 %, respectively trio_rvemvs performed competitively individual variants level rare variants may individual rare variants trio_rvemvs outperformed pedgene common variants rare variants real data 20 %, region level level kernel applying trio_rvemvs xlink "> variant extensions trio rvemvs paper proposes outperformed rv orofacial clefts functionally related complex diseases commonly reported bayesian framework average true available samples 74 %. 500 trios 350 trios 350 families 22 associated 1500 families |