<b>Engineered </b><b>VPg</b><b> </b><b>saRNA achieves cap-independent,</b><b> </b><b>low-immunogenic and precise</b><b> </b><b>encoding of therapeutic proteins </b><b>in vivo</b><b>.</b>
<p dir="ltr">AsPC-1 pancreatic cancer cells were transfected with the VPg-GSDMDeng saRNA vaccine and subsequently cultured for 15 consecutive passages to evaluate sequence stability during prolonged intracellular replication. Total RNA was isolated from both the first-generation (P1)...
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