Comparative cytotoxicity of free and nanoparticle-encapsulated ABT-199 and Vorinostat in colorectal cancer cells.

(A, B) Dose–response curves of free ABT-199 versus ABT-199-loaded nanoparticles (ABT-NPs) in HT-29 and HCT116 cells, respectively, after 72-hour treatment. (C, D) Dose–response curves of free Vorinostat versus Vorinostat-loaded nanoparticles (VOR-NPs) i...

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Bibliographic Details
Main Author:	Dina Raed Abu Alsamen (22410916) (author)
Other Authors:	Zainab Zaki Zakaraya (20448340) (author), Anas Abed (17940463) (author), Alhareth A. Alsa’d (17940466) (author), Maysoon Raed Alnajdawi (22410919) (author)
Published:	2025
Subjects:	Biochemistry Medicine Cell Biology Pharmacology Biotechnology Developmental Biology Cancer Virology Space Science Chemical Sciences not elsewhere classified tested molar ratios holds great potential cytotoxicity studies revealed control drug release bioavailability present challenges 49 &# 181 32 &# 181 04 &# 181 study initially focused maintained good stability histone deacetylase inhibitor 3 &# 8201 lowest ci values colorectal cancer cells ci values consistently 2 molar ratio 2 &# 8201 div >< p 6 &# 8201 1 molar ratio vorinostat exhibiting ic synergistic anticancer effects 199 displayed ic 5 %, respectively nps ), vorinostat 2 inhibitor synergistic effects study aimed nps ), enhance stability 3 activity values close proliferative effects hct116 cells apoptotic cells antiproliferative effects unencapsulated counterparts talalay method significantly increased pronounced synergy proliferative effect proliferative activity poor solubility nanoprecipitation method increasing caspase glycolic acid formulated using flow cytometry encapsulation efficiencies effective treatment
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Comparative cytotoxicity of free and nanoparticle-encapsulated ABT-199 and Vorinostat in colorectal cancer cells.

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