Synaptic changes under STDP and Anti-STDP in Hodgkin–Huxley-based network models with different connections, related to Fig 3.
<p><b>(A)</b> Schematic illustration and histogram for lognormal distributions of the number of synapses per neuron in different SDs. <b>(B, C)</b> Box plots for mean synaptic efficacy during sleep-like and wake-like firing patterns under STDP (<i>n</i> = 19...
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2025
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| Summary: | <p><b>(A)</b> Schematic illustration and histogram for lognormal distributions of the number of synapses per neuron in different SDs. <b>(B, C)</b> Box plots for mean synaptic efficacy during sleep-like and wake-like firing patterns under STDP (<i>n</i> = 191, 74, 46, 43, <i>n</i> = 52, 34, 26, 25, and <i>n</i> = 150, 83, 56, 48 for each value of SD in post-synaptic, intracellular and pre-synaptic bifurcation models, respectively) <b>(B)</b> and Anti-STDP (<i>n</i> = 121, 82, 57, 49, <i>n</i> = 36, 34, 34, 31, and <i>n</i> = 119, 90, 61, 58 for each value of SD in post-synaptic, intracellular and pre-synaptic bifurcation models, respectively) <b>(C)</b> in different SDs for lognormal distributions. <b>(D)</b> Schematic illustration and histogram for lognormal distributions of the number of synapses per neuron in different means. <b>(E, F)</b> Box plots for mean synaptic efficacy during sleep-like and wake-like firing patterns under STDP (<i>n</i> = 89, 191, 85, 83, <i>n</i> = 36, 52, 34, 34, and <i>n</i> = 99, 150, 90, 88 for each value of mean in post-synaptic, intracellular and pre-synaptic bifurcation models, respectively) <b>(E)</b> and Anti-STDP (<i>n</i> = 83, 121, 85, 77, <i>n</i> = 36, 36, 35, 38, and <i>n</i> = 101, 119, 93, 91 for each value of mean in post-synaptic, intracellular and pre-synaptic bifurcation models, respectively.) <b>(F)</b> in different means for lognormal distributions. <b>(B, C, E, F)</b> A parameter set for the synaptic learning rule was assigned to each network model. Synaptic efficacy was compared assuming the almost close firing rates between sleep-like and wake-like states. Initial synaptic efficacies of all synapses were 0.5. Simulations were conducted for 60 s and synaptic efficacy and CV were averaged over the period from 10 to 60 s. The whiskers above and below of box plots show minimal to maximal values. The box extends from the 25th to the 75th percentile and the middle line indicates the median. *<i>p</i> < 0.05, **<i>p</i> < 0.01, ***<i>p</i> < 0.001, ****<i>p</i> < 0.0001, Student <i>t</i> test was applied. The parameter se<i>t</i>s for channel and receptor conductance of network models and synaptic learning rules were the same as in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3003198#pbio.3003198.g003" target="_blank">Fig 3E</a> and <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3003198#pbio.3003198.g003" target="_blank">3F</a>. <i>n</i> represents the number of parameter sets for the network models. The data underlying the graphs shown in the figure can be found in Tables I and J in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3003198#pbio.3003198.s030" target="_blank">S2 Data</a>.</p> <p>(TIF)</p> |
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