Image 1_Different patterns of leukocyte immune responses to infection of ancestral SARS-CoV-2 and its variants.pdf
Background<p>Contributions of leukocytes to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) defense have been reported extensively. However, it remains unclear whether there are different leukocyte responses to ancestral SARS-CoV-2 and its variants.</p>Methods<p>We ana...
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2025
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| _version_ | 1852021240516050944 |
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| author | Yuanyuan Wu (82054) |
| author2 | Raphael Serna (21104846) Wenqi Gan (14127137) Zhichao Fan (3533123) |
| author2_role | author author author |
| author_facet | Yuanyuan Wu (82054) Raphael Serna (21104846) Wenqi Gan (14127137) Zhichao Fan (3533123) |
| author_role | author |
| dc.creator.none.fl_str_mv | Yuanyuan Wu (82054) Raphael Serna (21104846) Wenqi Gan (14127137) Zhichao Fan (3533123) |
| dc.date.none.fl_str_mv | 2025-04-17T05:23:03Z |
| dc.identifier.none.fl_str_mv | 10.3389/fcimb.2025.1508120.s001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/figure/Image_1_Different_patterns_of_leukocyte_immune_responses_to_infection_of_ancestral_SARS-CoV-2_and_its_variants_pdf/28814348 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Clinical Microbiology COVID-19 SARS-CoV-2 variant leukocyte neutrophil monocyte lymphocyte |
| dc.title.none.fl_str_mv | Image 1_Different patterns of leukocyte immune responses to infection of ancestral SARS-CoV-2 and its variants.pdf |
| dc.type.none.fl_str_mv | Image Figure info:eu-repo/semantics/publishedVersion image |
| description | Background<p>Contributions of leukocytes to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) defense have been reported extensively. However, it remains unclear whether there are different leukocyte responses to ancestral SARS-CoV-2 and its variants.</p>Methods<p>We analyzed peripheral blood leukocyte and subtype concentrations from 575 COVID-19 patients and 950 non-COVID-19 subjects registered at the University of Connecticut John Dempsey Hospital between 2020 and 2022, which covers the ancestral strain, Delta, and Omicron variants.</p>Results<p>We found that neutrophils, immature granulocytes, and monocytes were elevated, and lymphocytes were reduced after infection. These hyperactive neutrophils/immature granulocytes and suppressed lymphocytes/monocytes were associated with poorer prognosis in ancestral strain infection. Different from the ancestral strain, hyperactive immature granulocytes were not shown in the decedents of Delta infection, and immature granulocyte concentration was not observed to be associated with mortality. In Omicron infection, suppressed lymphocytes and monocytes were not shown in the decedents, and lymphocyte/monocyte concentrations were not associated with mortality.</p>Conclusions<p>Our findings provided insights into different leukocyte immune responses to ancestral SARS-CoV-2, Delta, and Omicron variants.</p> |
| eu_rights_str_mv | openAccess |
| id | Manara_f4006eb533ef0bf8a0e76dce549566ea |
| identifier_str_mv | 10.3389/fcimb.2025.1508120.s001 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/28814348 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Image 1_Different patterns of leukocyte immune responses to infection of ancestral SARS-CoV-2 and its variants.pdfYuanyuan Wu (82054)Raphael Serna (21104846)Wenqi Gan (14127137)Zhichao Fan (3533123)Clinical MicrobiologyCOVID-19SARS-CoV-2 variantleukocyteneutrophilmonocytelymphocyteBackground<p>Contributions of leukocytes to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) defense have been reported extensively. However, it remains unclear whether there are different leukocyte responses to ancestral SARS-CoV-2 and its variants.</p>Methods<p>We analyzed peripheral blood leukocyte and subtype concentrations from 575 COVID-19 patients and 950 non-COVID-19 subjects registered at the University of Connecticut John Dempsey Hospital between 2020 and 2022, which covers the ancestral strain, Delta, and Omicron variants.</p>Results<p>We found that neutrophils, immature granulocytes, and monocytes were elevated, and lymphocytes were reduced after infection. These hyperactive neutrophils/immature granulocytes and suppressed lymphocytes/monocytes were associated with poorer prognosis in ancestral strain infection. Different from the ancestral strain, hyperactive immature granulocytes were not shown in the decedents of Delta infection, and immature granulocyte concentration was not observed to be associated with mortality. In Omicron infection, suppressed lymphocytes and monocytes were not shown in the decedents, and lymphocyte/monocyte concentrations were not associated with mortality.</p>Conclusions<p>Our findings provided insights into different leukocyte immune responses to ancestral SARS-CoV-2, Delta, and Omicron variants.</p>2025-04-17T05:23:03ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.3389/fcimb.2025.1508120.s001https://figshare.com/articles/figure/Image_1_Different_patterns_of_leukocyte_immune_responses_to_infection_of_ancestral_SARS-CoV-2_and_its_variants_pdf/28814348CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/288143482025-04-17T05:23:03Z |
| spellingShingle | Image 1_Different patterns of leukocyte immune responses to infection of ancestral SARS-CoV-2 and its variants.pdf Yuanyuan Wu (82054) Clinical Microbiology COVID-19 SARS-CoV-2 variant leukocyte neutrophil monocyte lymphocyte |
| status_str | publishedVersion |
| title | Image 1_Different patterns of leukocyte immune responses to infection of ancestral SARS-CoV-2 and its variants.pdf |
| title_full | Image 1_Different patterns of leukocyte immune responses to infection of ancestral SARS-CoV-2 and its variants.pdf |
| title_fullStr | Image 1_Different patterns of leukocyte immune responses to infection of ancestral SARS-CoV-2 and its variants.pdf |
| title_full_unstemmed | Image 1_Different patterns of leukocyte immune responses to infection of ancestral SARS-CoV-2 and its variants.pdf |
| title_short | Image 1_Different patterns of leukocyte immune responses to infection of ancestral SARS-CoV-2 and its variants.pdf |
| title_sort | Image 1_Different patterns of leukocyte immune responses to infection of ancestral SARS-CoV-2 and its variants.pdf |
| topic | Clinical Microbiology COVID-19 SARS-CoV-2 variant leukocyte neutrophil monocyte lymphocyte |