M. tuberculosis ESX-3 periplasmic domain EccB3.

(a) EccB3 interactions with the five drugs having Z-scores values less than -1. (b) EccB3 dimer interface interaction with selamectin. (c) Molecular interactions between EccB3 interface residues and selamectin in 2D diagram. Ligplot was used for 2D map.

محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Ana Laura Granados-Tristán (21144439) (author)
مؤلفون آخرون:	Mauricio Carrillo-Tripp (3183507) (author), Carlos Eduardo Hernández-Luna (21144442) (author), Aldo Herrera-Rodulfo (21144445) (author), Laura Adiene González-Escalante (8890166) (author), Ana Leticia Arriaga-Guerrero (8890154) (author), Beatriz Silva-Ramírez (8890169) (author), Brenda Leticia Escobedo-Guajardo (18809428) (author), Roberto Mercado-Hernández (8890172) (author), Mario Bermúdez de León (21144448) (author), Katia Peñuelas-Urquides (11639896) (author)
منشور في:	2025
الموضوعات:	Biophysics Biochemistry Medicine Microbiology Molecular Biology Pharmacology Biotechnology Cancer Infectious Diseases Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified inhibited using crispri 3 secretion system favorable δg values tertiary protein structures new therapeutic targets eccd3 dimer interfaces div >< p mycolicibacterium smegmatis </ mycobacterium tuberculosis </ ivermectin susceptibility increased mycobacterium susceptibility smegmatis </ tuberculosis </ new drugs molecular structures ivermectin targets eccd3 protein eccd3 increased best δg resistant tuberculosis vitro </ silico </ eccd3 </ zinc homeostasis quaternary interface prospective drugs predicted based preclinical studies ivermectin action compensatory mechanisms
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الوصف
الملخص:	<p>(a) EccB3 interactions with the five drugs having Z-scores values less than -1. (b) EccB3 dimer interface interaction with selamectin. (c) Molecular interactions between EccB3 interface residues and selamectin in 2D diagram. Ligplot was used for 2D map.</p>

<i>M</i>. <i>tuberculosis</i> ESX-3 periplasmic domain EccB3.

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