Figure 5 from SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance

<p>A proposed model of ATRi resistance caused by SMG8/9 loss of function.</p>

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Autor principal:	Marta J. Llorca-Cardenosa (14961612) (author)
Otros Autores:	Lauren I. Aronson (14961615) (author), Dragomir B. Krastev (14961618) (author), Jadwiga Nieminuszczy (14961621) (author), John Alexander (14961624) (author), Feifei Song (14961627) (author), Malgorzata Dylewska (14961630) (author), Ronan Broderick (14961633) (author), Rachel Brough (14961636) (author), Astrid Zimmermann (14961639) (author), Frank T. Zenke (14961642) (author), Bora Gurel (14961645) (author), Ruth Riisnaes (14961648) (author), Ana Ferreira (14961651) (author), Theodoros Roumeliotis (14961654) (author), Jyoti Choudhary (14961657) (author), Stephen J. Pettitt (14952601) (author), Johann de Bono (14961660) (author), Andres Cervantes (14961663) (author), Syed Haider (14961666) (author), Wojciech Niedzwiedz (14961669) (author), Christopher J. Lord (14952616) (author), Irene Y. Chong (14961672) (author)
Publicado:	2025
Materias:	Cancer Molecular and Cellular Biology Therapeutic Research and Development DNA Damage and Repair DNA repair Drug Mechanisms Drug Resistance Gastrointestinal Cancers Stomach cancer
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author	Marta J. Llorca-Cardenosa (14961612)
author2	Lauren I. Aronson (14961615) Dragomir B. Krastev (14961618) Jadwiga Nieminuszczy (14961621) John Alexander (14961624) Feifei Song (14961627) Malgorzata Dylewska (14961630) Ronan Broderick (14961633) Rachel Brough (14961636) Astrid Zimmermann (14961639) Frank T. Zenke (14961642) Bora Gurel (14961645) Ruth Riisnaes (14961648) Ana Ferreira (14961651) Theodoros Roumeliotis (14961654) Jyoti Choudhary (14961657) Stephen J. Pettitt (14952601) Johann de Bono (14961660) Andres Cervantes (14961663) Syed Haider (14961666) Wojciech Niedzwiedz (14961669) Christopher J. Lord (14952616) Irene Y. Chong (14961672)
author2_role	author author author author author author author author author author author author author author author author author author author author author author
author_facet	Marta J. Llorca-Cardenosa (14961612) Lauren I. Aronson (14961615) Dragomir B. Krastev (14961618) Jadwiga Nieminuszczy (14961621) John Alexander (14961624) Feifei Song (14961627) Malgorzata Dylewska (14961630) Ronan Broderick (14961633) Rachel Brough (14961636) Astrid Zimmermann (14961639) Frank T. Zenke (14961642) Bora Gurel (14961645) Ruth Riisnaes (14961648) Ana Ferreira (14961651) Theodoros Roumeliotis (14961654) Jyoti Choudhary (14961657) Stephen J. Pettitt (14952601) Johann de Bono (14961660) Andres Cervantes (14961663) Syed Haider (14961666) Wojciech Niedzwiedz (14961669) Christopher J. Lord (14952616) Irene Y. Chong (14961672)
author_role	author
dc.creator.none.fl_str_mv	Marta J. Llorca-Cardenosa (14961612) Lauren I. Aronson (14961615) Dragomir B. Krastev (14961618) Jadwiga Nieminuszczy (14961621) John Alexander (14961624) Feifei Song (14961627) Malgorzata Dylewska (14961630) Ronan Broderick (14961633) Rachel Brough (14961636) Astrid Zimmermann (14961639) Frank T. Zenke (14961642) Bora Gurel (14961645) Ruth Riisnaes (14961648) Ana Ferreira (14961651) Theodoros Roumeliotis (14961654) Jyoti Choudhary (14961657) Stephen J. Pettitt (14952601) Johann de Bono (14961660) Andres Cervantes (14961663) Syed Haider (14961666) Wojciech Niedzwiedz (14961669) Christopher J. Lord (14952616) Irene Y. Chong (14961672)
dc.date.none.fl_str_mv	2025-11-24T22:40:22Z
dc.identifier.none.fl_str_mv	10.1158/0008-5472.30699130
dc.relation.none.fl_str_mv	https://figshare.com/articles/figure/Figure_5_from_SMG8_SMG9_Heterodimer_Loss_Modulates_SMG1_Kinase_to_Drive_ATR_Inhibitor_Resistance/30699130
dc.rights.none.fl_str_mv	CC BY info:eu-repo/semantics/openAccess
dc.subject.none.fl_str_mv	Cancer Molecular and Cellular Biology Therapeutic Research and Development DNA Damage and Repair DNA repair Drug Mechanisms Drug Resistance Gastrointestinal Cancers Stomach cancer
dc.title.none.fl_str_mv	Figure 5 from SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance
dc.type.none.fl_str_mv	Image Figure info:eu-repo/semantics/publishedVersion image
description	<p>A proposed model of ATRi resistance caused by SMG8/9 loss of function.</p>
eu_rights_str_mv	openAccess
id	Manara_f62971a3899cd229718a4f669d5a406e
identifier_str_mv	10.1158/0008-5472.30699130
network_acronym_str	Manara
network_name_str	ManaraRepo
oai_identifier_str	oai:figshare.com:article/30699130
publishDate	2025
repository.mail.fl_str_mv
repository.name.fl_str_mv
repository_id_str
rights_invalid_str_mv	CC BY
spelling	Figure 5 from SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor ResistanceMarta J. Llorca-Cardenosa (14961612)Lauren I. Aronson (14961615)Dragomir B. Krastev (14961618)Jadwiga Nieminuszczy (14961621)John Alexander (14961624)Feifei Song (14961627)Malgorzata Dylewska (14961630)Ronan Broderick (14961633)Rachel Brough (14961636)Astrid Zimmermann (14961639)Frank T. Zenke (14961642)Bora Gurel (14961645)Ruth Riisnaes (14961648)Ana Ferreira (14961651)Theodoros Roumeliotis (14961654)Jyoti Choudhary (14961657)Stephen J. Pettitt (14952601)Johann de Bono (14961660)Andres Cervantes (14961663)Syed Haider (14961666)Wojciech Niedzwiedz (14961669)Christopher J. Lord (14952616)Irene Y. Chong (14961672)CancerMolecular and Cellular BiologyTherapeutic Research and DevelopmentDNA Damage and RepairDNA repairDrug MechanismsDrug ResistanceGastrointestinal CancersStomach cancer<p>A proposed model of ATRi resistance caused by SMG8/9 loss of function.</p>2025-11-24T22:40:22ZImageFigureinfo:eu-repo/semantics/publishedVersionimage10.1158/0008-5472.30699130https://figshare.com/articles/figure/Figure_5_from_SMG8_SMG9_Heterodimer_Loss_Modulates_SMG1_Kinase_to_Drive_ATR_Inhibitor_Resistance/30699130CC BYinfo:eu-repo/semantics/openAccessoai:figshare.com:article/306991302025-11-24T22:40:22Z
spellingShingle	Figure 5 from SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance Marta J. Llorca-Cardenosa (14961612) Cancer Molecular and Cellular Biology Therapeutic Research and Development DNA Damage and Repair DNA repair Drug Mechanisms Drug Resistance Gastrointestinal Cancers Stomach cancer
status_str	publishedVersion
title	Figure 5 from SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance
title_full	Figure 5 from SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance
title_fullStr	Figure 5 from SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance
title_full_unstemmed	Figure 5 from SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance
title_short	Figure 5 from SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance
title_sort	Figure 5 from SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance
topic	Cancer Molecular and Cellular Biology Therapeutic Research and Development DNA Damage and Repair DNA repair Drug Mechanisms Drug Resistance Gastrointestinal Cancers Stomach cancer

Figure 5 from SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance

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