Supplementary Material for: Trait-like and State-like Oxytocin: A Biomarker of Alliance in Patients with Depression and Borderline Personality Disorder
Introduction: Patients with Major depressive disorder (MDD) and Borderline personality disorder (BPD) show a poorer prognosis compared to patients without BPD. A potential contributor is the complexity of establishing a therapeutic alliance with patients with BPD. A potential underlying biological m...
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2025
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| _version_ | 1849927633735778304 |
|---|---|
| author | figshare admin karger (2628495) |
| author2 | Peysachov G. (22681778) Tchizick A. (22681781) Delgadillo J. (22681784) Shamay-Tsoory S. (18322077) Zilcha-Mano S. (14332140) |
| author2_role | author author author author author |
| author_facet | figshare admin karger (2628495) Peysachov G. (22681778) Tchizick A. (22681781) Delgadillo J. (22681784) Shamay-Tsoory S. (18322077) Zilcha-Mano S. (14332140) |
| author_role | author |
| dc.creator.none.fl_str_mv | figshare admin karger (2628495) Peysachov G. (22681778) Tchizick A. (22681781) Delgadillo J. (22681784) Shamay-Tsoory S. (18322077) Zilcha-Mano S. (14332140) |
| dc.date.none.fl_str_mv | 2025-11-25T12:55:12Z |
| dc.identifier.none.fl_str_mv | 10.6084/m9.figshare.30706580.v1 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/dataset/Supplementary_Material_for_Trait-like_and_State-like_Oxytocin_A_Biomarker_of_Alliance_in_Patients_with_Depression_and_Borderline_Personality_Disorder/30706580 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Medicine Medicine |
| dc.title.none.fl_str_mv | Supplementary Material for: Trait-like and State-like Oxytocin: A Biomarker of Alliance in Patients with Depression and Borderline Personality Disorder |
| dc.type.none.fl_str_mv | Dataset info:eu-repo/semantics/publishedVersion dataset |
| description | Introduction: Patients with Major depressive disorder (MDD) and Borderline personality disorder (BPD) show a poorer prognosis compared to patients without BPD. A potential contributor is the complexity of establishing a therapeutic alliance with patients with BPD. A potential underlying biological mechanism is Oxytocin (OT), a hormone associated with social bonding and trust. The aim of this study was to assess whether the interaction between OT pre-session (session-level trait-like) and change in OT throughout session (state-like) in both patients and therapists predicts the therapeutic alliance in patients with MDD and varying severity of BPD. We hypothesized that patients with higher BPD severity would show a compensatory pattern, where increase in state-like OT would compensate for low session-level trait-like OT, resulting in a stronger alliance. We also explored this interplay in the therapists' OT. Method: Eighty-four patients from a randomized control trial were assessed for BPD severity prior to beginning 16 sessions of short-term psychotherapy. Both patients and therapists provided saliva samples pre- and post- sessions 4, 8, 12 and 16 for OT analysis. Alliance was measured post-session. A series of linear mixed-effects models was used to test the hypothesis. Results: Our hypothesis was partially confirmed. In patients with higher BPD severity, when therapists had low session-level trait-like OT, the more they increased in state-like OT, patients rated their alliance as stronger. However, this compensatory pattern did not emerge in patients. Conclusion: These findings demonstrate the potential importance of OT as a biomarker of therapeutic processes in patients with MDD and BPD. |
| eu_rights_str_mv | openAccess |
| id | Manara_f675e73e8c705a327296017c7d862ec7 |
| identifier_str_mv | 10.6084/m9.figshare.30706580.v1 |
| network_acronym_str | Manara |
| network_name_str | ManaraRepo |
| oai_identifier_str | oai:figshare.com:article/30706580 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Supplementary Material for: Trait-like and State-like Oxytocin: A Biomarker of Alliance in Patients with Depression and Borderline Personality Disorderfigshare admin karger (2628495)Peysachov G. (22681778)Tchizick A. (22681781)Delgadillo J. (22681784)Shamay-Tsoory S. (18322077)Zilcha-Mano S. (14332140)MedicineMedicineIntroduction: Patients with Major depressive disorder (MDD) and Borderline personality disorder (BPD) show a poorer prognosis compared to patients without BPD. A potential contributor is the complexity of establishing a therapeutic alliance with patients with BPD. A potential underlying biological mechanism is Oxytocin (OT), a hormone associated with social bonding and trust. The aim of this study was to assess whether the interaction between OT pre-session (session-level trait-like) and change in OT throughout session (state-like) in both patients and therapists predicts the therapeutic alliance in patients with MDD and varying severity of BPD. We hypothesized that patients with higher BPD severity would show a compensatory pattern, where increase in state-like OT would compensate for low session-level trait-like OT, resulting in a stronger alliance. We also explored this interplay in the therapists' OT. Method: Eighty-four patients from a randomized control trial were assessed for BPD severity prior to beginning 16 sessions of short-term psychotherapy. Both patients and therapists provided saliva samples pre- and post- sessions 4, 8, 12 and 16 for OT analysis. Alliance was measured post-session. A series of linear mixed-effects models was used to test the hypothesis. Results: Our hypothesis was partially confirmed. In patients with higher BPD severity, when therapists had low session-level trait-like OT, the more they increased in state-like OT, patients rated their alliance as stronger. However, this compensatory pattern did not emerge in patients. Conclusion: These findings demonstrate the potential importance of OT as a biomarker of therapeutic processes in patients with MDD and BPD.2025-11-25T12:55:12ZDatasetinfo:eu-repo/semantics/publishedVersiondataset10.6084/m9.figshare.30706580.v1https://figshare.com/articles/dataset/Supplementary_Material_for_Trait-like_and_State-like_Oxytocin_A_Biomarker_of_Alliance_in_Patients_with_Depression_and_Borderline_Personality_Disorder/30706580CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/307065802025-11-25T12:55:12Z |
| spellingShingle | Supplementary Material for: Trait-like and State-like Oxytocin: A Biomarker of Alliance in Patients with Depression and Borderline Personality Disorder figshare admin karger (2628495) Medicine Medicine |
| status_str | publishedVersion |
| title | Supplementary Material for: Trait-like and State-like Oxytocin: A Biomarker of Alliance in Patients with Depression and Borderline Personality Disorder |
| title_full | Supplementary Material for: Trait-like and State-like Oxytocin: A Biomarker of Alliance in Patients with Depression and Borderline Personality Disorder |
| title_fullStr | Supplementary Material for: Trait-like and State-like Oxytocin: A Biomarker of Alliance in Patients with Depression and Borderline Personality Disorder |
| title_full_unstemmed | Supplementary Material for: Trait-like and State-like Oxytocin: A Biomarker of Alliance in Patients with Depression and Borderline Personality Disorder |
| title_short | Supplementary Material for: Trait-like and State-like Oxytocin: A Biomarker of Alliance in Patients with Depression and Borderline Personality Disorder |
| title_sort | Supplementary Material for: Trait-like and State-like Oxytocin: A Biomarker of Alliance in Patients with Depression and Borderline Personality Disorder |
| topic | Medicine Medicine |