Coexpression is more often due to coregulation than edges.
<p>In the focal GRN from <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1013387#pcbi.1013387.g006" target="_blank">Fig 6</a>, we show a histogram of coexpression values split by whether pairs of genes share an edge (“A regulates B, or...
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2025
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| Summary: | <p>In the focal GRN from <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1013387#pcbi.1013387.g006" target="_blank">Fig 6</a>, we show a histogram of coexpression values split by whether pairs of genes share an edge (“A regulates B, or B regulates A”, share a regulator (“A and B are coregulated”), or have another relationship (left panel). Similarly, for perturbation effects, we show the distribution split by whether pairs of genes share an edge (“A regulates B”), a path of distance 2 (“A indirectly regulates B”), or another relationship (right panel). At nearly all levels of coexpression, coregulation is more common than direct regulation. Meanwhile, direct regulation is more common than indirect regulation for the largest perturbation effects—note that the range of KO effects is clipped as in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1013387#pcbi.1013387.g006" target="_blank">Fig 6</a>.</p> <p>(TIFF)</p> |
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