APP deficiency impairs the normal firing patterns of PCs.

APP deficiency impairs the normal firing patterns of PCs.

<p><b>(A)</b> Representative spontaneous firing patterns recorded in PCs of wild-type (<i>App</i><sup>+/+</sup>) mice. Pie charts in the right panel showing the percentage of PC firing pattern. <i>App</i><sup>+/+</sup>, <i>n<...

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Bibliografiske detaljer
Hovedforfatter:	Miao-Jin Ji (22676552) (author)
Andre forfattere:	Tong-Xuan Wu (22676555) (author), Chenhao Tian (10801643) (author), Xiang Cao (298023) (author), Ruyuan Wei (22676558) (author), Yin-Yin Yang (301866) (author), Xinran Meng (11537536) (author), Huanyao Tang (22676561) (author), Tiantao Cui (22676564) (author), Jiao Yang (623531) (author), Xin Tang (134573) (author), Chao Liu (43092) (author)
Udgivet:	2025
Fag:	Biochemistry Cell Biology Molecular Biology Neuroscience Physiology Developmental Biology Infectious Diseases mediated sodium currents deep cerebellar nucleus aberrant firing patterns specific app reconstitution cerebellar motor control app deficiency leads electrophysiological analysis revealed 6 channel activity motor performance motor function motor deficits app selectively purkinje cells marked reduction impaired locomotion findings reveal exogenous expression essential role dcn ). conditional knockdown behavioral deficits
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Lignende værker

Exogenous APP expression restored the Nav1.6 currents and ameliorated the abnormalities in the firing patterns of PCs of APP-null mice.
af: Miao-Jin Ji (22676552)
Udgivet: (2025)

PoTX potentiates persistent sodium currents in APP-null PCs.
af: Miao-Jin Ji (22676552)
Udgivet: (2025)

Nav1.6 mediated the deficits of PC firing and motor function in APP-null mice.
af: Miao-Jin Ji (22676552)
Udgivet: (2025)

APP deficiency selectively reduces Nav1.6-mediated Na<sup>+</sup> currents in cerebellar PCs.
af: Miao-Jin Ji (22676552)
Udgivet: (2025)

APP deficiency did not affect the mRNA level of <i>Scn8a</i> in cerebellar PCs.
af: Miao-Jin Ji (22676552)
Udgivet: (2025)

Full-length APP is required for the rescue of motor deficit in APP-null mice.
af: Miao-Jin Ji (22676552)
Udgivet: (2025)

Nav1.6 Mediates most of the persistent and resurgent sodium currents in cerebellar PCs.
af: Miao-Jin Ji (22676552)
Udgivet: (2025)

Validation of Nav1.6 and Nav1.1 contributions to sodium currents in PCs.
af: Miao-Jin Ji (22676552)
Udgivet: (2025)

L7 promoter-driven Cre recombinase expression is restricted to PCs in the cerebellar cortex.
af: Miao-Jin Ji (22676552)
Udgivet: (2025)

APP-null mice exhibit motor function deficits.
af: Miao-Jin Ji (22676552)
Udgivet: (2025)

APP deficiency does not alter PC development or induce degeneration.
af: Miao-Jin Ji (22676552)
Udgivet: (2025)

Exogenous amyloid precursor protein (APP) expression restored the defects of the sIPSCs evoked by Nav1.6-mediated Purkenji cell inputs in APP-null mice.
af: Miao-Jin Ji (22676552)
Udgivet: (2025)

Cerebellar Purkinje cell (PC)-specific amyloid precursor protein (APP) expression modulates motor function.
af: Miao-Jin Ji (22676552)
Udgivet: (2025)

Source data and statistical details for figures.
af: Miao-Jin Ji (22676552)
Udgivet: (2025)

Raw images for blots.
af: Miao-Jin Ji (22676552)
Udgivet: (2025)

xxx.
af: Miao-Jin Ji (22676552)
Udgivet: (2025)

Antibody validation for Nav1.6 and Nav1.1-EGFP in transfected HEK293 cells.
af: Miao-Jin Ji (22676552)
Udgivet: (2025)

Table 1_Videonystagmography features and clinical symptoms correlate with Parkinson's clinical subtypes.docx
af: Guangli Zheng (6680279)
Udgivet: (2025)

Table 1_Socioeconomic status and motor coordination function among children with autism.docx
af: Muqing Cao (8308815)
Udgivet: (2025)

Data sets
af: Mohammad Sidiq (16972449)
Udgivet: (2025)

Supplementary Materials: Propagation of Beta bursts from the motor cortex to the motor units of multiple upper-limb muscles
af: Shlomi Haar (7537199)
Udgivet: (2025)

الانعكاسات الواقعية لانعدام الإرادة التعاقدية في وثيقة التأمين الإلزامي للمركبات وحلول إرادة المنظم
af: Al Tarawneh, Abdallah Imhammad Khalaf
Udgivet: (2025)

Relative bias of the App-results.
af: Jette Hinrichsen (22683252)
Udgivet: (2025)

Bland-Altman-Plots for the difference between App and 24-hour-recall on Days 1, 2, 3 and the mean over the three days for ‘Beverages’.
af: Jette Hinrichsen (22683252)
Udgivet: (2025)

Bland-Altman-Plots for the difference between App and 24-hour-recall on Days 1, 2, 3 and the mean over the three days for fat.
af: Jette Hinrichsen (22683252)
Udgivet: (2025)

Bland-Altman-Plots for the difference between App and 24-hour-recall on Days 1, 2, 3 and the mean over the three days for carbohydrates.
af: Jette Hinrichsen (22683252)
Udgivet: (2025)

Bland-Altman-Plots for the difference between App and 24-hour-recall on Days 1, 2, 3 and the mean over the three days for protein.
af: Jette Hinrichsen (22683252)
Udgivet: (2025)

Bland-Altman-Plots for the difference between App and 24-hour-recall on Days 1, 2, 3 and the mean over the three days for calories.
af: Jette Hinrichsen (22683252)
Udgivet: (2025)

Bland-Altman-Plots for the difference between App and 24-hour-recall on Days 1, 2, 3 and the mean over the three days for ‘Fats and oils’.
af: Jette Hinrichsen (22683252)
Udgivet: (2025)

Bland-Altman-Plots for the difference between App and 24-hour-recall on Days 1, 2, 3 and the mean over the three days for ‘Milk and dairy’.
af: Jette Hinrichsen (22683252)
Udgivet: (2025)

Bland-Altman-Plots for the difference between App and 24-hour-recall on Days 1, 2, 3 and the mean over the three days for ‘Vegetables and salad’.
af: Jette Hinrichsen (22683252)
Udgivet: (2025)

Bland-Altman-Plots for the difference between App and 24-hour-recall on Days 1, 2, 3 and the mean over the three days for ‘Fruit and fruit juice’.
af: Jette Hinrichsen (22683252)
Udgivet: (2025)

Bland-Altman-Plots for the difference between App and 24-hour-recall on Days 1, 2, 3 and the mean over the three days for ‘Meat, sausage, fish and egg’.
af: Jette Hinrichsen (22683252)
Udgivet: (2025)

Bland-Altman-Plots for the difference between App and 24-hour-recall on Days 1, 2, 3 and the mean over the three days for ‘Grain, grain products and potatoes’.
af: Jette Hinrichsen (22683252)
Udgivet: (2025)

Table 1_The mechanism of social interaction deficits in attention-deficit/hyperactivity disorder children: the role of cognitive flexibility.docx
af: Zicheng Liu (1569883)
Udgivet: (2025)

Data Sheet 1_Herb-soil coupling in post-fire karst forests: a grey relational analysis in Yunnan, Southwest China.docx
af: Longhai Zhang (7424390)
Udgivet: (2025)

Study characteristics of the subjects in the present study (n = 97).
af: Jette Hinrichsen (22683252)
Udgivet: (2025)

Subject recruitment and Dropouts.
af: Jette Hinrichsen (22683252)
Udgivet: (2025)

Data sets and coding scripts for research on sensory processing in ADHD and ASD
af: Vesko Varbanov (9687029)
Udgivet: (2025)

Survey data from: Defining "resilient landscapes" from multiple stakeholder perspectives in a wildland-urban interface (WUI) area
af: Jody L. S. Jahn (19658449)
Udgivet: (2025)

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