APP deficiency impairs the normal firing patterns of PCs.

APP deficiency impairs the normal firing patterns of PCs.

<p><b>(A)</b> Representative spontaneous firing patterns recorded in PCs of wild-type (<i>App</i><sup>+/+</sup>) mice. Pie charts in the right panel showing the percentage of PC firing pattern. <i>App</i><sup>+/+</sup>, <i>n<...

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Príomhchruthaitheoir:	Miao-Jin Ji (22676552) (author)
Rannpháirtithe:	Tong-Xuan Wu (22676555) (author), Chenhao Tian (10801643) (author), Xiang Cao (298023) (author), Ruyuan Wei (22676558) (author), Yin-Yin Yang (301866) (author), Xinran Meng (11537536) (author), Huanyao Tang (22676561) (author), Tiantao Cui (22676564) (author), Jiao Yang (623531) (author), Xin Tang (134573) (author), Chao Liu (43092) (author)
Foilsithe / Cruthaithe:	2025
Ábhair:	Biochemistry Cell Biology Molecular Biology Neuroscience Physiology Developmental Biology Infectious Diseases mediated sodium currents deep cerebellar nucleus aberrant firing patterns specific app reconstitution cerebellar motor control app deficiency leads electrophysiological analysis revealed 6 channel activity motor performance motor function motor deficits app selectively purkinje cells marked reduction impaired locomotion findings reveal exogenous expression essential role dcn ). conditional knockdown behavioral deficits
Clibeanna:	Cuir clib leis Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!

Míreanna comhchosúla

Exogenous APP expression restored the Nav1.6 currents and ameliorated the abnormalities in the firing patterns of PCs of APP-null mice.
de réir: Miao-Jin Ji (22676552)
Foilsithe / Cruthaithe: (2025)

PoTX potentiates persistent sodium currents in APP-null PCs.
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Foilsithe / Cruthaithe: (2025)

Nav1.6 mediated the deficits of PC firing and motor function in APP-null mice.
de réir: Miao-Jin Ji (22676552)
Foilsithe / Cruthaithe: (2025)

APP deficiency selectively reduces Nav1.6-mediated Na<sup>+</sup> currents in cerebellar PCs.
de réir: Miao-Jin Ji (22676552)
Foilsithe / Cruthaithe: (2025)

APP deficiency did not affect the mRNA level of <i>Scn8a</i> in cerebellar PCs.
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Foilsithe / Cruthaithe: (2025)

Full-length APP is required for the rescue of motor deficit in APP-null mice.
de réir: Miao-Jin Ji (22676552)
Foilsithe / Cruthaithe: (2025)

Nav1.6 Mediates most of the persistent and resurgent sodium currents in cerebellar PCs.
de réir: Miao-Jin Ji (22676552)
Foilsithe / Cruthaithe: (2025)

Validation of Nav1.6 and Nav1.1 contributions to sodium currents in PCs.
de réir: Miao-Jin Ji (22676552)
Foilsithe / Cruthaithe: (2025)

L7 promoter-driven Cre recombinase expression is restricted to PCs in the cerebellar cortex.
de réir: Miao-Jin Ji (22676552)
Foilsithe / Cruthaithe: (2025)

APP-null mice exhibit motor function deficits.
de réir: Miao-Jin Ji (22676552)
Foilsithe / Cruthaithe: (2025)

APP deficiency does not alter PC development or induce degeneration.
de réir: Miao-Jin Ji (22676552)
Foilsithe / Cruthaithe: (2025)

Exogenous amyloid precursor protein (APP) expression restored the defects of the sIPSCs evoked by Nav1.6-mediated Purkenji cell inputs in APP-null mice.
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Source data and statistical details for figures.
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Foilsithe / Cruthaithe: (2025)

Raw images for blots.
de réir: Miao-Jin Ji (22676552)
Foilsithe / Cruthaithe: (2025)

xxx.
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Foilsithe / Cruthaithe: (2025)

Antibody validation for Nav1.6 and Nav1.1-EGFP in transfected HEK293 cells.
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Foilsithe / Cruthaithe: (2025)

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Foilsithe / Cruthaithe: (2025)

Bland-Altman-Plots for the difference between App and 24-hour-recall on Days 1, 2, 3 and the mean over the three days for calories.
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Foilsithe / Cruthaithe: (2025)

Bland-Altman-Plots for the difference between App and 24-hour-recall on Days 1, 2, 3 and the mean over the three days for ‘Fats and oils’.
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Foilsithe / Cruthaithe: (2025)

Bland-Altman-Plots for the difference between App and 24-hour-recall on Days 1, 2, 3 and the mean over the three days for ‘Milk and dairy’.
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Foilsithe / Cruthaithe: (2025)

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Foilsithe / Cruthaithe: (2025)

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Foilsithe / Cruthaithe: (2025)

Bland-Altman-Plots for the difference between App and 24-hour-recall on Days 1, 2, 3 and the mean over the three days for ‘Meat, sausage, fish and egg’.
de réir: Jette Hinrichsen (22683252)
Foilsithe / Cruthaithe: (2025)

Bland-Altman-Plots for the difference between App and 24-hour-recall on Days 1, 2, 3 and the mean over the three days for ‘Grain, grain products and potatoes’.
de réir: Jette Hinrichsen (22683252)
Foilsithe / Cruthaithe: (2025)

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