DDR2-Y740C kinase is more active than DDR2-WT kinase.
<p><b>A.</b> Schematic structure of the recombinant DDR2 constructs. JM4 tyrosines (Y521, Y538) and A-loop tyrosines (replaced by C740 in DDR2-K-Y740C) are labelled. The soluble DDR2-K-WT and DDR2-K-Y740C proteins were incubated at 0.1 µM in the presence of kinase buffer I and 1 mM...
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2025
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