DDR2-Y740C kinase is more active than DDR2-WT kinase.

<p><b>A.</b> Schematic structure of the recombinant DDR2 constructs. JM4 tyrosines (Y521, Y538) and A-loop tyrosines (replaced by C740 in DDR2-K-Y740C) are labelled. The soluble DDR2-K-WT and DDR2-K-Y740C proteins were incubated at 0.1 µM in the presence of kinase buffer I and 1 mM...

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Hlavní autor:	Ziteng Hao (22647882) (author)
Další autoři:	Birgit Leitinger (111622) (author)
Vydáno:	2025
Témata:	Biophysics Biochemistry Cell Biology Molecular Biology Biotechnology Immunology Infectious Diseases Virology Biological Sciences not elsewhere classified Chemical Sciences not elsewhere classified substrate phosphorylation rates mechanistic studies addressing key catalytic residues increased catalytic rates autosomal dominant manner atp binding affinity independent constitutive autophosphorylation missense variant bypasses y740c kinase constructs wt ddr2 kinase y740c kinase substituted variant missense mutations enhanced autophosphorylation ddr2 kinase ddr1 kinase y740c displayed wt ddr2 soluble wt xlink "> unphosphorylated ddr2 structural explanation skin fusion previously hypothesised mammalian cells length proteins keloid plaques function mechanism enzyme kinetics corneal vascularisation cinotti variants cinotti syndrome cause disease autoinhibitory constraints
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DDR2-Y740C kinase is more active than DDR2-WT kinase.

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