Quercetin restored ultrastructure of endoplasmic reticulum in cortical neurons in hyperglycemic MCAO/R rats.

<p>(A-D) Representative TEM image of cortical neurons in the penumbra in hyperglycemic MCAO/R rats. Scale bar = 2μm, ×10000. (E-H) Local magnification, scale bar =1μm, ×30000. The double-membrane ER structures with ribosomes are marked by black arrows, mitochondria are marked by green arrows,...

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محفوظ في:

التفاصيل البيبلوغرافية
المؤلف الرئيسي:	Jing Yang (13969) (author)
مؤلفون آخرون:	Yan-Mei Ma (8767593) (author), Lan Yang (457660) (author), Peng Li (69518) (author), Li Jing (445177) (author), P. Andy Li (9326666) (author), Jian-Zhong Zhang (10920444) (author)
منشور في:	2025
الموضوعات:	Biochemistry Medicine Microbiology Cell Biology Genetics Molecular Biology Neuroscience Physiology Pharmacology Immunology Chemical Sciences not elsewhere classified neurological deficit score cerebral infarct volume alleviated neuron damage oxygen glucose deprivation hyperglycemia exacerbated ciri quercetin pretreatment decreased div >< p injected hyperglycemic rats treating hyperglycemic ciri sirt1 signaling pathway quercetin inhibits ers perk pathway high glucose reducing ciri hyperglycemic condition ciri ). ameliorating ciri quercetin upregulated quercetin could sirt1 </ results demonstrated r rats normoglycemic condition neuroprotective drugs mediated apoptosis inhibiting ers ht22 cells findings indicate activating sirt1 527 blocked
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Quercetin restored ultrastructure of endoplasmic reticulum in cortical neurons in hyperglycemic MCAO/R rats.

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