Allowable parameter space (APS) for the proposed subcircuit mediating dynamic allodynia.
<p><b>(A)</b> A schematic of the dynamic subcircuit. <i>I1</i> and <i>I2</i> represent the populations of inhibitory neurons, and <i>E1</i> and <i>E2</i> represent the populations of excitatory neurons. We assume the <i>E2</i...
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2025
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| Summary: | <p><b>(A)</b> A schematic of the dynamic subcircuit. <i>I1</i> and <i>I2</i> represent the populations of inhibitory neurons, and <i>E1</i> and <i>E2</i> represent the populations of excitatory neurons. We assume the <i>E2</i> population relays signals to projection neurons. <i>Aβ</i> represents inputs to the subcircuit, relayed from the periphery along <i>Aβ</i> fibers. <b>(B)</b> The mean (black lines) and range (shaded gray areas) for the firing rate (top left) and voltage (top right) of the <i>E2</i> population, as well as for the firing rates of the I2 (middle left), E1 (middle right), and I1 (bottom left) populations calculated across 20 sampled sets of coupling strengths each with a different random input <i>Aβ</i> stimulus (active during <i>t</i> ∈ [0.2, 0.7] s). <b>(C)</b> Violin plots of distributions of coupling strength values in the APS. The vertical bar represents the values within one standard deviation of the mean (square marker) for the corresponding coupling strength. <b>(D)</b> Normalized Pearson’s correlation coefficients between coupling strength values across sampled sets in the APS.</p> |
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