Assessment of direct binding of OY25 and OY29 to DNA by competitive intercalation assays and molecular docking studies.

Assessment of direct binding of OY25 and OY29 to DNA by competitive intercalation assays and molecular docking studies.

<p>(A) Ethidium bromide competition for assessment of interaction of OY25 and OY29 with human genomic DNA. (Ai) 0.8% (w/v) ethidium bromide-stained agarose gel containing DNA extracted from HCC70 breast cancer cells. + : cisplatin). (Aii) The average fluorescence intensity (n = 3, with SEM), r...

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Bibliographic Details
Main Author: Nyeleti Vukea (8903750) (author)
Other Authors: Ogunyemi Oderinlo (21736192) (author), Matshawandile Tukulula (1871668) (author), Setshaba David Khanye (21736195) (author), Adrienne Lesley Edkins (8903759) (author), Jo-Anne de la Mare (3843361) (author)
Published: 2025
Subjects:
Biochemistry
Cell Biology
Genetics
Molecular Biology
Pharmacology
Cancer
Space Science
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Chemical Sciences not elsewhere classified
swissadme web tool
moderate micromolar range
based assays revealed
24 &# 956
07 &# 956
compounds acted synergistically
tumourigenic cell lines
oy29 acted synergistically
negative breast cancer
hcc70 tnbc cells
div >< p
cell lines
two compounds
tnbc poses
therapeutic challenge
silico </
oy29 show
oy29 ).
minor groove
less toxic
key receptors
inducing drugs
dual mode
docking analysis
disease predominant
dione derivatives
containing thiazolidine
african descent
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