Comparison of accuracy metrics (sensitivity, specificity, and AUC ROC) of each model defined by what subset of data was used for training and testing.

Comparison of accuracy metrics (sensitivity, specificity, and AUC ROC) of each model defined by what subset of data was used for training and testing.

<p>For models with convergence issues an NA is presented.</p> <p>(XLSX)</p>

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書誌詳細
第一著者:	Marco Hamins-Puértolas (15238661) (author)
その他の著者:	Darunee Buddhari (625855) (author), Henrik Salje (589157) (author), Angkana T. Huang (12262139) (author), Taweewun Hunsawong (798675) (author), Derek A.T. Cummings (14971341) (author), Stefan Fernandez (146590) (author), Aaron Farmer (4288318) (author), Surachai Kaewhiran (22683535) (author), Direk Khampaen (22683538) (author), Anon Srikiatkhachorn (110184) (author), Sopon Iamsirithaworn (260152) (author), Adam Waickman (118668) (author), Stephen J. Thomas (7105673) (author), Timothy Endy (150971) (author), Alan L. Rothman (6835178) (author), Kathryn B. Anderson (6835166) (author), Isabel Rodriguez-Barraquer (233670) (author)
出版事項:	2025
主題:	Medicine Biotechnology Ecology Immunology Cancer Science Policy Infectious Diseases Virology Computational Biology Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Chemical Sciences not elsewhere classified since many cases linked immunosorbent assay independently utilize information hemagglutination inhibition assay globe &# 8217 currently implemented cut convalescent serum collected 87 &# 8211 82 &# 8211 real world data multiple serological assays infer infection events generate finalized interpretations bayesian mixture model prior standard interpretations pcr confirmed infections jointly model data gold standard ). f1 scores ). hai data consistently direct detection methods gold standard f1 scores infection detection eia ). including data individual assays new model igm data whether individuals transmission potential results provide recently experienced provide insight probabilistic framework population living point approaches pathogen systems kamphaeng phet interpreting results incorporating igg important role higher accuracy first test diagnostic process creating uncertainty combined metric already half 677 pairs
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Comparison of each accuracy metric (sensitivity, specificity, F1, and area under the curve for reporter operator curve (AUC ROC)) on each model. Models are defined by which assays were incorporated (i.e., HAI, IgG, and/or IgM). Bolded values represent the best performing model for the infection definition and metric of interest.
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Acute and convalescent serological data from Thai cohorts used in this analyses, colored by true infections status and prediction of infection during model testing.
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Simulated serological data using serosim and subsequent results using the full mixture model on (a) HAI, (b) IgG and (c) IgM data with additional observational noise.
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Theoretical relationship between time since symptom onset and titers in one infected (red) and three uninfected (blue) individuals.
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