Sequence and structure of ENP and MEL4.

Sequence and structure of ENP and MEL4.

<p>A) AlphaFold-predicted structure for ENP [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011217#pgen.1011217.ref027" target="_blank">27</a>,<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011217...

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Main Author: Michaela S. Matthes (21587677) (author)
Other Authors: Nicole Yun (21587680) (author), Miriam Luichtl (21587683) (author), Ulrich Büschges (21587686) (author), Birgit S. Fiesselmann (21587689) (author), Benjamin Strickland (21587692) (author), Marietta S. Lehnardt (21587695) (author), Kay Schneitz (221050) (author), Klaus Michel (478992) (author), Ramon A. Torres Ruiz (21587698) (author)
Published: 2025
Subjects:
Biophysics
Biochemistry
Medicine
Cell Biology
Genetics
Molecular Biology
Neuroscience
Evolutionary Biology
Ecology
Developmental Biology
Infectious Diseases
Plant Biology
Virology
similar polar localization
intrinsically disordered region
div >< p
three structured domains
double mutants lead
fret shows enp
polar pin1 activity
pinoid hold information
flower organ development
results show enp
pins including pin1
auxin transporter pin
enp pid </
single mutants
flower development
distinct domains
pid </
enp predicted
enp offers
arabidopsis </
supporting pin1
mediated pin1
significantly interact
potential interactor
plasma membrane
plant leaf
multiprotein complex
modular structure
modification status
less plants
kinase pinoid
independent input
develop cotyledons
completely dispensable
closely associated
assumed pin
alphafold separates
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Summary:<p>A) AlphaFold-predicted structure for ENP [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011217#pgen.1011217.ref027" target="_blank">27</a>,<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011217#pgen.1011217.ref028" target="_blank">28</a>]. B) AlphaFold-predicted structure for MEL4/NPY4. Inset shows turn of the terminal region to highlight position of amino acid R450 (the analogue of R468 in ENP). Studied amino acid residues are indicated with arrows and position. Color code for the per residue confidence metrics in A and B) dark blue: pLDDT>90, light blue: 90 > pLDDT>70, yellow: 70 > pLDDT>50, orange pLDDT<50. C) Protein similarity schemes. The upper bar code compares MEL4 with ENP and the proteins MEL1-3; the lower ENP with MEL1-4; given are gray to black lines, indicating degree of similarity. Note the C-terminal region of ENP vs. the much shorter terminal region of MEL4. The inset depicts a similarity tree between these proteins based on Clustal comparison (<a href="https://www.ebi.ac.uk/jdispatcher/msa/clustalo" target="_blank">https://www.ebi.ac.uk/jdispatcher/msa/clustalo</a>). A schematic drawing indicates the regions tentatively separated by sequence similarity and AlphaFold-predicted structure.</p>

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