Reduced survival upon HFCC diet-feeding of older SR-B1<sup>KO/KO</sup> mice.

Reduced survival upon HFCC diet-feeding of older SR-B1<sup>KO/KO</sup> mice.

<p>Kaplan-Meier survival curves for <b>(A)</b> 14-week-old (w.o.) (solid blue line, n = 13) and 40 w.o. (dotted black line, n = 13) C57BL/6J (WT) mice and <b>(B)</b> 14 w.o. (solid blue line, n = 14) and 40 w.o. (dotted black line, n = 14) <i>SR-B1</i><su...

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Bibliographic Details
Main Author:	Samuel K. Lee (14392425) (author)
Other Authors:	Ting Xiong (1302621) (author), Alexander S. Qian (14240508) (author), Jeong-Ah Yoo (21410468) (author), B. Sumayyah H. Sokeechand (21410471) (author), Mark T. Fuller (14392416) (author), Peter L. Gross (9150097) (author), Richard C. Austin (14392428) (author), Suleiman A. Igdoura (14392431) (author), Bernardo L. Trigatti (445281) (author)
Published:	2025
Subjects:	Medicine Cell Biology Genetics Physiology Biotechnology Immunology Developmental Biology Mental Health Infectious Diseases Computational Biology neutrophil marker myeloperoxidase major risk factor greater inflammatory state developed similar degrees attractive mouse model coronary artery disease coronary artery atherothrombosis increased inflammatory state dependent mechanisms associated xlink "> sr coronary artery plaques younger aged mice either 14 weeks female homozygous sr studies directly examine mice lacking sr coronary artery atherosclerosis increased myocardial fibrosis older aged sr fed homozygous sr increased circulating neutrophils aged hfcc diet b1 knockout mice aged sr homozygous sr myocardial fibrosis coronary arteries increased levels increased abundance dependent manner circulating interleukin atherosclerotic plaques fed sr 40 weeks 12 weeks platelet accumulation plasma levels normal diet may facilitate induced atherosclerosis humane endpoint effective therapeutics early death cardiac troponin b1 alone atherosclerosis development atherogenic mutations apolipoprotein e aortic sinuses aortic sinus
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Summary:	<p>Kaplan-Meier survival curves for <b>(A)</b> 14-week-old (w.o.) (solid blue line, n = 13) and 40 w.o. (dotted black line, n = 13) C57BL/6J (WT) mice and <b>(B)</b> 14 w.o. (solid blue line, n = 14) and 40 w.o. (dotted black line, n = 14) <i>SR-B1</i><sup><i>KO/KO</i></sup> (KO) mice fed the HFCC diet for up to 20 weeks and 40 w.o. <i>SR-B1</i><sup><i>KO/KO</i></sup> (KO) mice maintained on normal diet for an additional 20 weeks (solid red line, n = 12). Mice were monitored until they reached cardiac endpoint or the end of 20 weeks of diet feeding, at which point they were humanely euthanized. Data were analyzed by the Mantel-Cox log-rank test. ****P < 0.0001; ns = not statistically significantly different.</p>