Mechanical perturbation control of cardiac alternans
Cardiac alternans is a disturbance in heart rhythm that is linked to the onset of lethal cardiac arrhythmias. Mechanical perturbation control has been recently used to suppress alternans in cardiac tissue of relevant size. In this control strategy, cardiac tissue mechanics are perturbed via active t...
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2018
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| Online Access: | http://hdl.handle.net/11073/16638 |
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| _version_ | 1864513440720093184 |
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| author | Hazim, Azzam |
| author2 | Belhamadia, Youssef Dubljevic, Stevan |
| author2_role | author author |
| author_facet | Hazim, Azzam Belhamadia, Youssef Dubljevic, Stevan |
| author_role | author |
| dc.creator.none.fl_str_mv | Hazim, Azzam Belhamadia, Youssef Dubljevic, Stevan |
| dc.date.none.fl_str_mv | 2018 2020-02-27T07:31:34Z 2020-02-27T07:31:34Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | 2470-0053 http://hdl.handle.net/11073/16638 10.1103/PhysRevE.97.052407 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | American Physical Society |
| dc.relation.none.fl_str_mv | https://doi.org/10.1103/PhysRevE.97.052407 |
| dc.title.none.fl_str_mv | Mechanical perturbation control of cardiac alternans |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Cardiac alternans is a disturbance in heart rhythm that is linked to the onset of lethal cardiac arrhythmias. Mechanical perturbation control has been recently used to suppress alternans in cardiac tissue of relevant size. In this control strategy, cardiac tissue mechanics are perturbed via active tension generated by the heart’s electrical activity, which alters the tissue’s electric wave profile through mechanoelectric coupling. We analyze the effects of mechanical perturbation on the dynamics of amap model that couples themembrane voltage and active tension systems at the cellular level. Therefore, a two-dimensional iterative map of the heart beat-to-beat dynamics is introduced, and a stability analysis of the system of coupled maps is performed in the presence of a mechanical perturbation algorithm. To this end, a bidirectional coupling between the membrane voltage and active tension systems in a single cardiac cell is provided, and a discrete form of the proposed control algorithm, that can be incorporated in the coupled maps, is derived. In addition, a realistic electromechanical model of cardiac tissue is employed to explore the feasibility of suppressing alternans at cellular and tissue levels. Electrical activity is represented in two detailed ionic models, the Luo-Rudy 1 and the Fox models, while two active contractile tension models, namely a smooth variant of the Nash-Panfilov model and the Niederer-Hunter-Smith model, are used to represent mechanical activity in the heart. The Mooney-Rivlin passive elasticity model is employed to describe passive mechanical behavior of the myocardium. |
| format | article |
| id | aus_00d795f5a1d9db9dfdf482289ef35f80 |
| identifier_str_mv | 2470-0053 10.1103/PhysRevE.97.052407 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/16638 |
| publishDate | 2018 |
| publisher.none.fl_str_mv | American Physical Society |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
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| spelling | Mechanical perturbation control of cardiac alternansHazim, AzzamBelhamadia, YoussefDubljevic, StevanCardiac alternans is a disturbance in heart rhythm that is linked to the onset of lethal cardiac arrhythmias. Mechanical perturbation control has been recently used to suppress alternans in cardiac tissue of relevant size. In this control strategy, cardiac tissue mechanics are perturbed via active tension generated by the heart’s electrical activity, which alters the tissue’s electric wave profile through mechanoelectric coupling. We analyze the effects of mechanical perturbation on the dynamics of amap model that couples themembrane voltage and active tension systems at the cellular level. Therefore, a two-dimensional iterative map of the heart beat-to-beat dynamics is introduced, and a stability analysis of the system of coupled maps is performed in the presence of a mechanical perturbation algorithm. To this end, a bidirectional coupling between the membrane voltage and active tension systems in a single cardiac cell is provided, and a discrete form of the proposed control algorithm, that can be incorporated in the coupled maps, is derived. In addition, a realistic electromechanical model of cardiac tissue is employed to explore the feasibility of suppressing alternans at cellular and tissue levels. Electrical activity is represented in two detailed ionic models, the Luo-Rudy 1 and the Fox models, while two active contractile tension models, namely a smooth variant of the Nash-Panfilov model and the Niederer-Hunter-Smith model, are used to represent mechanical activity in the heart. The Mooney-Rivlin passive elasticity model is employed to describe passive mechanical behavior of the myocardium.American Physical Society2020-02-27T07:31:34Z2020-02-27T07:31:34Z2018Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdf2470-0053http://hdl.handle.net/11073/1663810.1103/PhysRevE.97.052407en_UShttps://doi.org/10.1103/PhysRevE.97.052407oai:repository.aus.edu:11073/166382024-08-22T12:01:42Z |
| spellingShingle | Mechanical perturbation control of cardiac alternans Hazim, Azzam |
| status_str | publishedVersion |
| title | Mechanical perturbation control of cardiac alternans |
| title_full | Mechanical perturbation control of cardiac alternans |
| title_fullStr | Mechanical perturbation control of cardiac alternans |
| title_full_unstemmed | Mechanical perturbation control of cardiac alternans |
| title_short | Mechanical perturbation control of cardiac alternans |
| title_sort | Mechanical perturbation control of cardiac alternans |
| url | http://hdl.handle.net/11073/16638 |