Ultrasound-induced doxorubicin release from folate-targeted and non-targeted P105 micelles: a modeling study
The aim of this work is to study the kinetics of ultrasound (70 kHz) – using a kinetic model that takes into account cavitation events and drug re-encapsulation upon the cessation of the acoustic field. The simulation allowed the determination of three parameters α, β and λ that define the release a...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| التنسيق: | article |
| منشور في: |
2016
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/21310 |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513437964435456 |
|---|---|
| author | Martins, Ana M. |
| author2 | Tanbour, Rafeeq Kamal Elkhodiry, Mohamed A. Husseini, Ghaleb |
| author2_role | author author author |
| author_facet | Martins, Ana M. Tanbour, Rafeeq Kamal Elkhodiry, Mohamed A. Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | Martins, Ana M. Tanbour, Rafeeq Kamal Elkhodiry, Mohamed A. Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2016 2021-02-02T07:47:25Z 2021-02-02T07:47:25Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Martins, Ana M., Tanbour, Rafeeq, Elkhodiry, Mohammed A. and Husseini, Ghaleb A.. "Ultrasound-induced doxorubicin release from folate-targeted and non-targeted P105 micelles: a modeling study" European Journal of Nanomedicine, vol. 8, no. 1, 2016, pp. 17-29. https://doi.org/10.1515/ejnm-2015-0045 1662-596X http://hdl.handle.net/11073/21310 10.1515/ejnm-2015-0045 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | De Gruyter |
| dc.relation.none.fl_str_mv | https://doi.org/10.1515/ejnm-2015-0045 |
| dc.subject.none.fl_str_mv | Cavitation Dox Folic acid Micelles Pluronic® P105 Ultrasound |
| dc.title.none.fl_str_mv | Ultrasound-induced doxorubicin release from folate-targeted and non-targeted P105 micelles: a modeling study |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The aim of this work is to study the kinetics of ultrasound (70 kHz) – using a kinetic model that takes into account cavitation events and drug re-encapsulation upon the cessation of the acoustic field. The simulation allowed the determination of three parameters α, β and λ that define the release and re-encapsulation behavior of this drug delivery system (DDS). The results showed that the drug release increased with increasing power density, as evidenced by the correlation between α and power density. The micelle re-assembly, quantified by the parameter β, also increased with increasing power density. The parameter λ, which is associated with the initial phase of the release process, showed a constant value regardless of the power density. The significance of these results was discussed. Additionally, a comparison between these parameters in folate-targeted and non-targeted micelles showed statistically significant differences for several power densities examined. A better understanding of the kinetics involved in this DDS is very important for the determination of the optimum ultrasound parameters to be used in future in vitro and in vivo experiments. |
| format | article |
| id | aus_09f9084f90ac6cbdbdae439b5d065cea |
| identifier_str_mv | Martins, Ana M., Tanbour, Rafeeq, Elkhodiry, Mohammed A. and Husseini, Ghaleb A.. "Ultrasound-induced doxorubicin release from folate-targeted and non-targeted P105 micelles: a modeling study" European Journal of Nanomedicine, vol. 8, no. 1, 2016, pp. 17-29. https://doi.org/10.1515/ejnm-2015-0045 1662-596X 10.1515/ejnm-2015-0045 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/21310 |
| publishDate | 2016 |
| publisher.none.fl_str_mv | De Gruyter |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Ultrasound-induced doxorubicin release from folate-targeted and non-targeted P105 micelles: a modeling studyMartins, Ana M.Tanbour, Rafeeq KamalElkhodiry, Mohamed A.Husseini, GhalebCavitationDoxFolic acidMicellesPluronic® P105UltrasoundThe aim of this work is to study the kinetics of ultrasound (70 kHz) – using a kinetic model that takes into account cavitation events and drug re-encapsulation upon the cessation of the acoustic field. The simulation allowed the determination of three parameters α, β and λ that define the release and re-encapsulation behavior of this drug delivery system (DDS). The results showed that the drug release increased with increasing power density, as evidenced by the correlation between α and power density. The micelle re-assembly, quantified by the parameter β, also increased with increasing power density. The parameter λ, which is associated with the initial phase of the release process, showed a constant value regardless of the power density. The significance of these results was discussed. Additionally, a comparison between these parameters in folate-targeted and non-targeted micelles showed statistically significant differences for several power densities examined. A better understanding of the kinetics involved in this DDS is very important for the determination of the optimum ultrasound parameters to be used in future in vitro and in vivo experiments.De Gruyter2021-02-02T07:47:25Z2021-02-02T07:47:25Z2016Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfMartins, Ana M., Tanbour, Rafeeq, Elkhodiry, Mohammed A. and Husseini, Ghaleb A.. "Ultrasound-induced doxorubicin release from folate-targeted and non-targeted P105 micelles: a modeling study" European Journal of Nanomedicine, vol. 8, no. 1, 2016, pp. 17-29. https://doi.org/10.1515/ejnm-2015-00451662-596Xhttp://hdl.handle.net/11073/2131010.1515/ejnm-2015-0045en_UShttps://doi.org/10.1515/ejnm-2015-0045oai:repository.aus.edu:11073/213102024-08-22T12:04:28Z |
| spellingShingle | Ultrasound-induced doxorubicin release from folate-targeted and non-targeted P105 micelles: a modeling study Martins, Ana M. Cavitation Dox Folic acid Micelles Pluronic® P105 Ultrasound |
| status_str | publishedVersion |
| title | Ultrasound-induced doxorubicin release from folate-targeted and non-targeted P105 micelles: a modeling study |
| title_full | Ultrasound-induced doxorubicin release from folate-targeted and non-targeted P105 micelles: a modeling study |
| title_fullStr | Ultrasound-induced doxorubicin release from folate-targeted and non-targeted P105 micelles: a modeling study |
| title_full_unstemmed | Ultrasound-induced doxorubicin release from folate-targeted and non-targeted P105 micelles: a modeling study |
| title_short | Ultrasound-induced doxorubicin release from folate-targeted and non-targeted P105 micelles: a modeling study |
| title_sort | Ultrasound-induced doxorubicin release from folate-targeted and non-targeted P105 micelles: a modeling study |
| topic | Cavitation Dox Folic acid Micelles Pluronic® P105 Ultrasound |
| url | http://hdl.handle.net/11073/21310 |