Scorpion and Frog Organ Lysates are Potential Source of Antitumour Activity
It is noteworthy that several animal species are known to withstand high levels of radiation, and are exposed to heavy metals but rarely been reported to develop cancer. For example, the scorpion has been used as folk medicine in ancient civilizations of Iran and China, while amphibian skin is known...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , |
| التنسيق: | article |
| منشور في: |
2020
|
| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/21452 |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513437487333376 |
|---|---|
| author | Soopramanien, Morhanavallee |
| author2 | Khan, Naveed Abdelnasir, Sumayah Sagathevan, K Siddiqui, Ruqaiyyah |
| author2_role | author author author author |
| author_facet | Soopramanien, Morhanavallee Khan, Naveed Abdelnasir, Sumayah Sagathevan, K Siddiqui, Ruqaiyyah |
| author_role | author |
| dc.creator.none.fl_str_mv | Soopramanien, Morhanavallee Khan, Naveed Abdelnasir, Sumayah Sagathevan, K Siddiqui, Ruqaiyyah |
| dc.date.none.fl_str_mv | 2020 2021-04-27T08:09:46Z 2021-04-27T08:09:46Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Soopramanien M, Khan NA, Abdalla SAO, Sagathevan K, Siddiqui R. Scorpion and Frog Organ Lysates are Potential Source of Antitumour Activity. Asian Pacific Journal of Cancer Prevention : APJCP. 2020 Oct;21(10):3011-3018. DOI: 10.31557/apjcp.2020.21.10.3011. 1513-7368 http://hdl.handle.net/11073/21452 10.31557/APJCP.2020.21.10.3011 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | Asian Pacific Organization for Cancer Prevention (APOCP) |
| dc.relation.none.fl_str_mv | http://journal.waocp.org/article_89299.html |
| dc.subject.none.fl_str_mv | Scorpion Anticancer effects Frog Cytotoxicity Growth inhibition |
| dc.title.none.fl_str_mv | Scorpion and Frog Organ Lysates are Potential Source of Antitumour Activity |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | It is noteworthy that several animal species are known to withstand high levels of radiation, and are exposed to heavy metals but rarely been reported to develop cancer. For example, the scorpion has been used as folk medicine in ancient civilizations of Iran and China, while amphibian skin is known to possess medicinal properties. Here, we elucidated the anti-tumour activity of the scorpion (Uropygi) and frog (Lithobates catesbeianus). Materials and Methods: Animals were procured and their organ lysates and sera were prepared and tested against Michigan Cancer Foundation-7 breast cancer (MCF-7), prostate cancer (PC3), Henrietta Lacks cervical cancer (HeLa), and normal human keratinocyte cells. Exoskeleton, appendages and hepatopancreas were dissected from the scorpion, whereas liver, lungs, heart, oviduct, gastrointestinal tract, gall bladder, kidneys, eggs and sera were collected from frog and organ lysates/sera were prepared. Growth inhibition assays and cytotoxicity assays were performed. Results: Appendages, exoskeleton lysates, and hepatopancreas from scorpion exhibited potent growth inhibition, and cytotoxic effects. Furthermore, lungs, liver, gastrointestinal tract, heart, oviduct, kidneys, eggs, and sera from frog displayed growth inhibition and cytotoxic effects. Conclusion: Organ lysates, sera of scorpion, and amphibians possess anti-tumour activities. This is a worthy area of research as the molecular identity of the active molecule(s) together with their mechanism of action will lead to the rational development of novel anticancer agent(s). |
| format | article |
| id | aus_0a1425bd3a3770080847677b9cd1192d |
| identifier_str_mv | Soopramanien M, Khan NA, Abdalla SAO, Sagathevan K, Siddiqui R. Scorpion and Frog Organ Lysates are Potential Source of Antitumour Activity. Asian Pacific Journal of Cancer Prevention : APJCP. 2020 Oct;21(10):3011-3018. DOI: 10.31557/apjcp.2020.21.10.3011. 1513-7368 10.31557/APJCP.2020.21.10.3011 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/21452 |
| publishDate | 2020 |
| publisher.none.fl_str_mv | Asian Pacific Organization for Cancer Prevention (APOCP) |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Scorpion and Frog Organ Lysates are Potential Source of Antitumour ActivitySoopramanien, MorhanavalleeKhan, NaveedAbdelnasir, SumayahSagathevan, KSiddiqui, RuqaiyyahScorpionAnticancer effectsFrogCytotoxicityGrowth inhibitionIt is noteworthy that several animal species are known to withstand high levels of radiation, and are exposed to heavy metals but rarely been reported to develop cancer. For example, the scorpion has been used as folk medicine in ancient civilizations of Iran and China, while amphibian skin is known to possess medicinal properties. Here, we elucidated the anti-tumour activity of the scorpion (Uropygi) and frog (Lithobates catesbeianus). Materials and Methods: Animals were procured and their organ lysates and sera were prepared and tested against Michigan Cancer Foundation-7 breast cancer (MCF-7), prostate cancer (PC3), Henrietta Lacks cervical cancer (HeLa), and normal human keratinocyte cells. Exoskeleton, appendages and hepatopancreas were dissected from the scorpion, whereas liver, lungs, heart, oviduct, gastrointestinal tract, gall bladder, kidneys, eggs and sera were collected from frog and organ lysates/sera were prepared. Growth inhibition assays and cytotoxicity assays were performed. Results: Appendages, exoskeleton lysates, and hepatopancreas from scorpion exhibited potent growth inhibition, and cytotoxic effects. Furthermore, lungs, liver, gastrointestinal tract, heart, oviduct, kidneys, eggs, and sera from frog displayed growth inhibition and cytotoxic effects. Conclusion: Organ lysates, sera of scorpion, and amphibians possess anti-tumour activities. This is a worthy area of research as the molecular identity of the active molecule(s) together with their mechanism of action will lead to the rational development of novel anticancer agent(s).American University of SharjahAsian Pacific Organization for Cancer Prevention (APOCP)2021-04-27T08:09:46Z2021-04-27T08:09:46Z2020Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSoopramanien M, Khan NA, Abdalla SAO, Sagathevan K, Siddiqui R. Scorpion and Frog Organ Lysates are Potential Source of Antitumour Activity. Asian Pacific Journal of Cancer Prevention : APJCP. 2020 Oct;21(10):3011-3018. DOI: 10.31557/apjcp.2020.21.10.3011.1513-7368http://hdl.handle.net/11073/2145210.31557/APJCP.2020.21.10.3011en_UShttp://journal.waocp.org/article_89299.htmloai:repository.aus.edu:11073/214522024-08-22T11:59:47Z |
| spellingShingle | Scorpion and Frog Organ Lysates are Potential Source of Antitumour Activity Soopramanien, Morhanavallee Scorpion Anticancer effects Frog Cytotoxicity Growth inhibition |
| status_str | publishedVersion |
| title | Scorpion and Frog Organ Lysates are Potential Source of Antitumour Activity |
| title_full | Scorpion and Frog Organ Lysates are Potential Source of Antitumour Activity |
| title_fullStr | Scorpion and Frog Organ Lysates are Potential Source of Antitumour Activity |
| title_full_unstemmed | Scorpion and Frog Organ Lysates are Potential Source of Antitumour Activity |
| title_short | Scorpion and Frog Organ Lysates are Potential Source of Antitumour Activity |
| title_sort | Scorpion and Frog Organ Lysates are Potential Source of Antitumour Activity |
| topic | Scorpion Anticancer effects Frog Cytotoxicity Growth inhibition |
| url | http://hdl.handle.net/11073/21452 |