Gold-Conjugated Curcumin as a Novel Therapeutic Agent against Brain-Eating Amoebae
Balamuthia mandrillaris and Naegleria fowleri are free-living amoebae that cause infection of the central nervous system, granulomatous amoebic encephalitis (GAE) and primary amoebic meningoencephalitis (PAM), respectively. The fact that mortality rates for cases of GAE and PAM are more than 95% ind...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| التنسيق: | article |
| منشور في: |
2020
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| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/21454 |
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| _version_ | 1864513432392302592 |
|---|---|
| author | Mungroo, Mohammad Ridwane |
| author2 | Anwar, Ayaz Khan, Naveed Siddiqui, Ruqaiyyah |
| author2_role | author author author |
| author_facet | Mungroo, Mohammad Ridwane Anwar, Ayaz Khan, Naveed Siddiqui, Ruqaiyyah |
| author_role | author |
| dc.creator.none.fl_str_mv | Mungroo, Mohammad Ridwane Anwar, Ayaz Khan, Naveed Siddiqui, Ruqaiyyah |
| dc.date.none.fl_str_mv | 2020 2021-04-27T09:16:58Z 2021-04-27T09:16:58Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Mungroo MR, Anwar A, Khan NA, Siddiqui R. Gold-Conjugated Curcumin as a Novel Therapeutic Agent against Brain-Eating Amoebae. ACS Omega. 2020;5(21):12467-12475. Published 2020 May 18. doi:10.1021/acsomega.0c01305 2470-1343 http://hdl.handle.net/11073/21454 10.1021/acsomega.0c01305 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | ACS Publications |
| dc.relation.none.fl_str_mv | https://doi.org/10.1021/acsomega.0c01305 |
| dc.title.none.fl_str_mv | Gold-Conjugated Curcumin as a Novel Therapeutic Agent against Brain-Eating Amoebae |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Balamuthia mandrillaris and Naegleria fowleri are free-living amoebae that cause infection of the central nervous system, granulomatous amoebic encephalitis (GAE) and primary amoebic meningoencephalitis (PAM), respectively. The fact that mortality rates for cases of GAE and PAM are more than 95% indicates the need for new therapeutic agents against those amoebae. Considering that curcumin exhibits a wide range of biological properties and has shown efficacy against Acanthamoeba castellanii, we evaluated the amoebicidal properties of curcumin against N. fowleri and B. mandrillaris. Curcumin showed significant amoebicidal activities with an AC₅₀ of 172 and 74 μM against B. mandrillaris and N. fowleri, respectively. Moreover, these compounds were also conjugated with gold nanoparticles to further increase their amoebicidal activities. After conjugation with gold nanoparticles, amoebicidal activities of the drugs were increased by up to 56 and 37% against B. mandrillaris and N. fowleri, respectively. These findings are remarkable and suggest that clinically available curcumin and our gold-conjugated curcumin nanoparticles hold promise in the improved treatment of fatal infections caused by brain-eating amoebae and should serve as a model in the rationale development of therapeutic interventions against other infections. |
| format | article |
| id | aus_0b1ae5c20b35ea14a8508b2abb62afc3 |
| identifier_str_mv | Mungroo MR, Anwar A, Khan NA, Siddiqui R. Gold-Conjugated Curcumin as a Novel Therapeutic Agent against Brain-Eating Amoebae. ACS Omega. 2020;5(21):12467-12475. Published 2020 May 18. doi:10.1021/acsomega.0c01305 2470-1343 10.1021/acsomega.0c01305 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/21454 |
| publishDate | 2020 |
| publisher.none.fl_str_mv | ACS Publications |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
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| spelling | Gold-Conjugated Curcumin as a Novel Therapeutic Agent against Brain-Eating AmoebaeMungroo, Mohammad RidwaneAnwar, AyazKhan, NaveedSiddiqui, RuqaiyyahBalamuthia mandrillaris and Naegleria fowleri are free-living amoebae that cause infection of the central nervous system, granulomatous amoebic encephalitis (GAE) and primary amoebic meningoencephalitis (PAM), respectively. The fact that mortality rates for cases of GAE and PAM are more than 95% indicates the need for new therapeutic agents against those amoebae. Considering that curcumin exhibits a wide range of biological properties and has shown efficacy against Acanthamoeba castellanii, we evaluated the amoebicidal properties of curcumin against N. fowleri and B. mandrillaris. Curcumin showed significant amoebicidal activities with an AC₅₀ of 172 and 74 μM against B. mandrillaris and N. fowleri, respectively. Moreover, these compounds were also conjugated with gold nanoparticles to further increase their amoebicidal activities. After conjugation with gold nanoparticles, amoebicidal activities of the drugs were increased by up to 56 and 37% against B. mandrillaris and N. fowleri, respectively. These findings are remarkable and suggest that clinically available curcumin and our gold-conjugated curcumin nanoparticles hold promise in the improved treatment of fatal infections caused by brain-eating amoebae and should serve as a model in the rationale development of therapeutic interventions against other infections.American University of SharjahACS Publications2021-04-27T09:16:58Z2021-04-27T09:16:58Z2020Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfMungroo MR, Anwar A, Khan NA, Siddiqui R. Gold-Conjugated Curcumin as a Novel Therapeutic Agent against Brain-Eating Amoebae. ACS Omega. 2020;5(21):12467-12475. Published 2020 May 18. doi:10.1021/acsomega.0c013052470-1343http://hdl.handle.net/11073/2145410.1021/acsomega.0c01305en_UShttps://doi.org/10.1021/acsomega.0c01305oai:repository.aus.edu:11073/214542024-08-22T11:59:23Z |
| spellingShingle | Gold-Conjugated Curcumin as a Novel Therapeutic Agent against Brain-Eating Amoebae Mungroo, Mohammad Ridwane |
| status_str | publishedVersion |
| title | Gold-Conjugated Curcumin as a Novel Therapeutic Agent against Brain-Eating Amoebae |
| title_full | Gold-Conjugated Curcumin as a Novel Therapeutic Agent against Brain-Eating Amoebae |
| title_fullStr | Gold-Conjugated Curcumin as a Novel Therapeutic Agent against Brain-Eating Amoebae |
| title_full_unstemmed | Gold-Conjugated Curcumin as a Novel Therapeutic Agent against Brain-Eating Amoebae |
| title_short | Gold-Conjugated Curcumin as a Novel Therapeutic Agent against Brain-Eating Amoebae |
| title_sort | Gold-Conjugated Curcumin as a Novel Therapeutic Agent against Brain-Eating Amoebae |
| url | http://hdl.handle.net/11073/21454 |