Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review
Glioblastoma (GBM) is a highly aggressive brain tumor, and its treatment is further complicated by the high selectivity of the blood–brain barrier (BBB). The scientific community is urgently seeking innovative and effective therapeutic solutions. Liposomes are a promising new tool that has shown pot...
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2023
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| Online Access: | http://hdl.handle.net/11073/25301 |
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| _version_ | 1864513438794907648 |
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| author | Kawak, Paul S. |
| author2 | AlSawaftah, Nour Majdi Pitt, William G. Husseini, Ghaleb |
| author2_role | author author author |
| author_facet | Kawak, Paul S. AlSawaftah, Nour Majdi Pitt, William G. Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | Kawak, Paul S. AlSawaftah, Nour Majdi Pitt, William G. Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2023-08-29T04:50:04Z 2023-08-29T04:50:04Z 2023-08-26 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Kawak, P., Sawaftah, N. M. A., Pitt, W. G., & Husseini, G. A. (2023). Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review. In International Journal of Molecular Sciences (Vol. 24, Issue 17, p. 13262). MDPI AG. https://doi.org/10.3390/ijms241713262 1422-0067 http://hdl.handle.net/11073/25301 10.3390/ijms241713262 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.relation.none.fl_str_mv | https://doi.org/10.3390/ijms241713262 |
| dc.subject.none.fl_str_mv | Cancer Glioblastoma Blood-brain barrier Liposomes Targeted drug delivery Transferrin |
| dc.title.none.fl_str_mv | Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Glioblastoma (GBM) is a highly aggressive brain tumor, and its treatment is further complicated by the high selectivity of the blood–brain barrier (BBB). The scientific community is urgently seeking innovative and effective therapeutic solutions. Liposomes are a promising new tool that has shown potential in addressing the limitations of chemotherapy, such as poor bioavailability and toxicity to healthy cells. However, passive targeting strategies based solely on the physicochemical properties of liposomes have proven ineffective due to a lack of tissue specificity. Accordingly, the upregulation of transferrin receptors (TfRs) in brain tissue has led to the development of TfR-targeted anticancer therapeutics. Currently, one of the most widely adopted methods for improving drug delivery in the treatment of GBM and other neurological disorders is the utilization of active targeting strategies that specifically target this receptor. In this review, we discuss the role of Tf-conjugated liposomes in GBM therapy and present some recent studies investigating the drug delivery efficiency of Tf-liposomes; in addition, we address some challenges currently facing this approach to treatment and present some potential improvement possibilities. |
| format | article |
| id | aus_13cf47b7f564c38f4a5f59e32ebf8102 |
| identifier_str_mv | Kawak, P., Sawaftah, N. M. A., Pitt, W. G., & Husseini, G. A. (2023). Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review. In International Journal of Molecular Sciences (Vol. 24, Issue 17, p. 13262). MDPI AG. https://doi.org/10.3390/ijms241713262 1422-0067 10.3390/ijms241713262 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/25301 |
| publishDate | 2023 |
| publisher.none.fl_str_mv | MDPI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Transferrin-Targeted Liposomes in Glioblastoma Therapy: A ReviewKawak, Paul S.AlSawaftah, Nour MajdiPitt, William G.Husseini, GhalebCancerGlioblastomaBlood-brain barrierLiposomesTargeted drug deliveryTransferrinGlioblastoma (GBM) is a highly aggressive brain tumor, and its treatment is further complicated by the high selectivity of the blood–brain barrier (BBB). The scientific community is urgently seeking innovative and effective therapeutic solutions. Liposomes are a promising new tool that has shown potential in addressing the limitations of chemotherapy, such as poor bioavailability and toxicity to healthy cells. However, passive targeting strategies based solely on the physicochemical properties of liposomes have proven ineffective due to a lack of tissue specificity. Accordingly, the upregulation of transferrin receptors (TfRs) in brain tissue has led to the development of TfR-targeted anticancer therapeutics. Currently, one of the most widely adopted methods for improving drug delivery in the treatment of GBM and other neurological disorders is the utilization of active targeting strategies that specifically target this receptor. In this review, we discuss the role of Tf-conjugated liposomes in GBM therapy and present some recent studies investigating the drug delivery efficiency of Tf-liposomes; in addition, we address some challenges currently facing this approach to treatment and present some potential improvement possibilities.American University of SharjahAl-Jalila FoundationAl Qasimi FoundationPatient's Friends Committee of SharjahBiosciences and Bioengineering Research InstituteGCC Co-Fund ProgramTakamul programTechnology Innovation Pioneer (TIP) Healthcare AwardsSheikh Hamdan Award for Medical SciencesFriends of Cancer Patients (FoCP)Dana Gas Endowed Chair for Chemical EngineeringMDPI2023-08-29T04:50:04Z2023-08-29T04:50:04Z2023-08-26Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfKawak, P., Sawaftah, N. M. A., Pitt, W. G., & Husseini, G. A. (2023). Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review. In International Journal of Molecular Sciences (Vol. 24, Issue 17, p. 13262). MDPI AG. https://doi.org/10.3390/ijms2417132621422-0067http://hdl.handle.net/11073/2530110.3390/ijms241713262en_UShttps://doi.org/10.3390/ijms241713262oai:repository.aus.edu:11073/253012024-09-11T10:47:46Z |
| spellingShingle | Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review Kawak, Paul S. Cancer Glioblastoma Blood-brain barrier Liposomes Targeted drug delivery Transferrin |
| status_str | publishedVersion |
| title | Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review |
| title_full | Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review |
| title_fullStr | Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review |
| title_full_unstemmed | Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review |
| title_short | Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review |
| title_sort | Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review |
| topic | Cancer Glioblastoma Blood-brain barrier Liposomes Targeted drug delivery Transferrin |
| url | http://hdl.handle.net/11073/25301 |