Stromal Adipocyte Enhancer-binding Protein (AEBP1) Promotes Mammary Epithelial Cell Hyperplasia via Proinflammatory and Hedgehog Signaling

Stromal Adipocyte Enhancer-binding Protein (AEBP1) Promotes Mammary Epithelial Cell Hyperplasia via Proinflammatory and Hedgehog Signaling

Disruption of mammary stromal-epithelial communication leads to aberrant mammary gland development and induces mammary tumorigenesis. Macrophages have been implicated in carcinogenesis primarily by creating an inflammatory microenvironment, which promotes growth of the adjacent epithelial cells. Adi...

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Bibliographic Details
Main Author: Holloway, Ryan W. (author)
Other Authors: Bogachev, Oleg (author), Bharadwaj, Alamelu G. (author), McCluske, Greg D. (author), Majdalawieh, Amin (author), Zhang, Lei (author), Ro, Hyo-Sung (author)
Format: article
Published: 2012
Subjects:
Breast Cancer
Inflammation
Macrophages
Mammary Gland
NF-κ B (NF-KB)
Transgenic Mice
Tumor Necrosis Factor (TNF)
Bone Marrow Transplantation
Hyperplasia
Sonic Hedgehog
Online Access:http://hdl.handle.net/11073/25054
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