Ultrasound-responsive Nanocarriers in Cancer Treatment: a review
The safe and effective delivery of anticancer agents to diseased tissues is one of the significant challenges in cancer therapy. Conventional anticancer agents are generally cytotoxins with poor pharmacokinetics and bioavailability. Nanocarriers are nanosized particles designed to the selectivity of...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , , |
| التنسيق: | article |
| منشور في: |
2021
|
| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/21488 |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513436645326848 |
|---|---|
| author | Awad, Nahid S. |
| author2 | Paul, Vinod Haar, Gail ter Allen, Theresa M. Pitt, William G. AlSawaftah, Nour Majdi Husseini, Ghaleb |
| author2_role | author author author author author author |
| author_facet | Awad, Nahid S. Paul, Vinod Haar, Gail ter Allen, Theresa M. Pitt, William G. AlSawaftah, Nour Majdi Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | Awad, Nahid S. Paul, Vinod Haar, Gail ter Allen, Theresa M. Pitt, William G. AlSawaftah, Nour Majdi Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2021-05-25T09:37:22Z 2021-05-25T09:37:22Z 2021 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Awad, N. S., Paul, V., AlSawaftah, N. M., ter Haar, G., Allen, T. M., Pitt, W. G., & Husseini, G. A. (2021). Ultrasound-Responsive Nanocarriers in Cancer Treatment: A Review. ACS Pharmacology & Translational Science, 4(2), 589–612. https://doi.org/10.1021/acsptsci.0c00212 2575-9108 http://hdl.handle.net/11073/21488 10.1021/acsptsci.0c00212 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | American Chemical Society |
| dc.relation.none.fl_str_mv | https://doi.org/10.1021/acsptsci.0c00212 |
| dc.subject.none.fl_str_mv | Nanocarriers Chemotherapy Ultrasound Drug release |
| dc.title.none.fl_str_mv | Ultrasound-responsive Nanocarriers in Cancer Treatment: a review |
| dc.type.none.fl_str_mv | Peer-Reviewed Preprint info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The safe and effective delivery of anticancer agents to diseased tissues is one of the significant challenges in cancer therapy. Conventional anticancer agents are generally cytotoxins with poor pharmacokinetics and bioavailability. Nanocarriers are nanosized particles designed to the selectivity of anti-cancer drugs and genes transport to tumors. They are small enough to extravasate into solid tumors where they slowly release their therapeutic load by passive leakage or by biodegradation. Using smart nanocarriers, the rate of release of the entrapped therapeutic(s) can be increased, and greater exposure of the tumor cells to the therapeutics can be achieved when the nanocarriers are exposed to certain internally (enzymes, pH and temperature) or externally applied (light, magnetic field, and ultrasound) stimuli that trigger the release of their load in a safe and controlled manner, spatially and temporally. This review gives a comprehensive overview of recent research findings on the different types of stimuli-responsive nanocarriers and their application in cancer treatment, with a particular focus on ultrasound. |
| format | article |
| id | aus_1e91767dc96f64f1a3606a5b828f90f9 |
| identifier_str_mv | Awad, N. S., Paul, V., AlSawaftah, N. M., ter Haar, G., Allen, T. M., Pitt, W. G., & Husseini, G. A. (2021). Ultrasound-Responsive Nanocarriers in Cancer Treatment: A Review. ACS Pharmacology & Translational Science, 4(2), 589–612. https://doi.org/10.1021/acsptsci.0c00212 2575-9108 10.1021/acsptsci.0c00212 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/21488 |
| publishDate | 2021 |
| publisher.none.fl_str_mv | American Chemical Society |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Ultrasound-responsive Nanocarriers in Cancer Treatment: a reviewAwad, Nahid S.Paul, VinodHaar, Gail terAllen, Theresa M.Pitt, William G.AlSawaftah, Nour MajdiHusseini, GhalebNanocarriersChemotherapyUltrasoundDrug releaseThe safe and effective delivery of anticancer agents to diseased tissues is one of the significant challenges in cancer therapy. Conventional anticancer agents are generally cytotoxins with poor pharmacokinetics and bioavailability. Nanocarriers are nanosized particles designed to the selectivity of anti-cancer drugs and genes transport to tumors. They are small enough to extravasate into solid tumors where they slowly release their therapeutic load by passive leakage or by biodegradation. Using smart nanocarriers, the rate of release of the entrapped therapeutic(s) can be increased, and greater exposure of the tumor cells to the therapeutics can be achieved when the nanocarriers are exposed to certain internally (enzymes, pH and temperature) or externally applied (light, magnetic field, and ultrasound) stimuli that trigger the release of their load in a safe and controlled manner, spatially and temporally. This review gives a comprehensive overview of recent research findings on the different types of stimuli-responsive nanocarriers and their application in cancer treatment, with a particular focus on ultrasound.American University of SharjahAl-Jalila FoundationAl Qasimi FoundationPatient's Friends Committee-SharjahBiosciences and Bioengineering Research InstituteGCC Co-Fund ProgramTakamul programTechnology Innovation Pioneer (TIP) Healthcare AwardsDana Gas Endowed Chair for Chemical EngineeringAmerican Chemical Society2021-05-25T09:37:22Z2021-05-25T09:37:22Z2021Peer-ReviewedPreprintinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfAwad, N. S., Paul, V., AlSawaftah, N. M., ter Haar, G., Allen, T. M., Pitt, W. G., & Husseini, G. A. (2021). Ultrasound-Responsive Nanocarriers in Cancer Treatment: A Review. ACS Pharmacology & Translational Science, 4(2), 589–612. https://doi.org/10.1021/acsptsci.0c002122575-9108http://hdl.handle.net/11073/2148810.1021/acsptsci.0c00212en_UShttps://doi.org/10.1021/acsptsci.0c00212oai:repository.aus.edu:11073/214882024-08-22T12:05:48Z |
| spellingShingle | Ultrasound-responsive Nanocarriers in Cancer Treatment: a review Awad, Nahid S. Nanocarriers Chemotherapy Ultrasound Drug release |
| status_str | publishedVersion |
| title | Ultrasound-responsive Nanocarriers in Cancer Treatment: a review |
| title_full | Ultrasound-responsive Nanocarriers in Cancer Treatment: a review |
| title_fullStr | Ultrasound-responsive Nanocarriers in Cancer Treatment: a review |
| title_full_unstemmed | Ultrasound-responsive Nanocarriers in Cancer Treatment: a review |
| title_short | Ultrasound-responsive Nanocarriers in Cancer Treatment: a review |
| title_sort | Ultrasound-responsive Nanocarriers in Cancer Treatment: a review |
| topic | Nanocarriers Chemotherapy Ultrasound Drug release |
| url | http://hdl.handle.net/11073/21488 |