Preparation and characterization of gatifloxacin-loaded sodium alginate hydrogel membranes supplemented with hydroxypropyl methylcellulose and hydroxypropyl cellulose polymers for wound dressing
Introduction: The aim of this study is to evaluate gatifloxacin-loaded sodium alginate hydrogel membranes, supplemented with glycerol (a plasticizer), glutaraldehyde (a cross-linking agent), and hydroxypropyl methylcellulose (HPMC) or hydroxypropyl cellulose (HPC) polymers, as potential wound dressi...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , , |
| التنسيق: | article |
| منشور في: |
2016
|
| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/25051 |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513439366381568 |
|---|---|
| author | Prabu, Durai |
| author2 | Majdalawieh, Amin Abu-Yousef, Imad Inbasekaran, Kadambari Balasubramaniam, Tharani Nallaperumal, Narayanan Gunasekar, Conjeevaram J. |
| author2_role | author author author author author author |
| author_facet | Prabu, Durai Majdalawieh, Amin Abu-Yousef, Imad Inbasekaran, Kadambari Balasubramaniam, Tharani Nallaperumal, Narayanan Gunasekar, Conjeevaram J. |
| author_role | author |
| dc.creator.none.fl_str_mv | Prabu, Durai Majdalawieh, Amin Abu-Yousef, Imad Inbasekaran, Kadambari Balasubramaniam, Tharani Nallaperumal, Narayanan Gunasekar, Conjeevaram J. |
| dc.date.none.fl_str_mv | 2016 2022-10-25T08:40:14Z 2022-10-25T08:40:14Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Prabu D, Majdalawieh AF, Abu-Yousef IA, Inbasekaran K, Balasubramaniam T, Nallaperumal N, Gunasekar CJ. Preparation and characterization of gatifloxacin-loaded sodium alginate hydrogel membranes supplemented with hydroxypropyl methylcellulose and hydroxypropyl cellulose polymers for wound dressing. Int J Pharma Investig 2016;6:86-95. 2230-9713 http://hdl.handle.net/11073/25051 10.4103/2230-973X.177810 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | PKP |
| dc.relation.none.fl_str_mv | https://doi.org/10.4103/2230-973X.177810 |
| dc.subject.none.fl_str_mv | Gatifloxacin Hydrogel membrane In vitro drug release Sodium alginate Wound dressing |
| dc.title.none.fl_str_mv | Preparation and characterization of gatifloxacin-loaded sodium alginate hydrogel membranes supplemented with hydroxypropyl methylcellulose and hydroxypropyl cellulose polymers for wound dressing |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Introduction: The aim of this study is to evaluate gatifloxacin-loaded sodium alginate hydrogel membranes, supplemented with glycerol (a plasticizer), glutaraldehyde (a cross-linking agent), and hydroxypropyl methylcellulose (HPMC) or hydroxypropyl cellulose (HPC) polymers, as potential wound dressing materials based on their physicochemical properties and the sustain-release phenomenon. Materials and Methods: The physicochemical properties of the prepared hydrogel membranes were evaluated by several methods including Fourier transform infrared and differential scanning calorimetry. Different techniques were used to assess the swelling behavior, tensile strength and elongation, % moisture absorption, % moisture loss, water vapor transmission rate (WVTR), and microbial penetration for the hydrogel membranes. In vitro gatifloxacin release from the hydrogel membranes was examined using the United States Pharmacopeia XXIII dissolution apparatus. Four kinetics models (zero-order, first-order, Higuchi equation, and Korsmeyer- Peppas equation) were applied to study drug release kinetics. Results: The addition of glycerol, glutaraldehyde, HPMC, and HPC polymers resulted in a considerable increase in the tensile strength and flexibility/elasticity of the hydrogel membranes. WVTR results suggest that hydrated hydrogel membranes can facilitate water vapor transfer. None of the hydrogel membranes supported microbial growth. HPMC-treated and HPC-treated hydrogel membranes allow slow, but sustained, release of gatifloxacin for 48 h. Drug release kinetics revealed that both diffusion and dissolution play an important role in gatifloxacin release. Conclusions: Given their physicochemical properties and gatifloxacin release pattern, HPMC-treated and HPC-treated hydrogel membranes exhibit effective and sustained drug release. Furthermore, HPMC-treated and HPC-treated hydrogel membranes possess physiochemical properties that make them effective and safe wound dressing materials. |
| format | article |
| id | aus_20e73dc7dcdf0d785cc6507347c9fad1 |
| identifier_str_mv | Prabu D, Majdalawieh AF, Abu-Yousef IA, Inbasekaran K, Balasubramaniam T, Nallaperumal N, Gunasekar CJ. Preparation and characterization of gatifloxacin-loaded sodium alginate hydrogel membranes supplemented with hydroxypropyl methylcellulose and hydroxypropyl cellulose polymers for wound dressing. Int J Pharma Investig 2016;6:86-95. 2230-9713 10.4103/2230-973X.177810 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/25051 |
| publishDate | 2016 |
| publisher.none.fl_str_mv | PKP |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Preparation and characterization of gatifloxacin-loaded sodium alginate hydrogel membranes supplemented with hydroxypropyl methylcellulose and hydroxypropyl cellulose polymers for wound dressingPrabu, DuraiMajdalawieh, AminAbu-Yousef, ImadInbasekaran, KadambariBalasubramaniam, TharaniNallaperumal, NarayananGunasekar, Conjeevaram J.GatifloxacinHydrogel membraneIn vitro drug releaseSodium alginateWound dressingIntroduction: The aim of this study is to evaluate gatifloxacin-loaded sodium alginate hydrogel membranes, supplemented with glycerol (a plasticizer), glutaraldehyde (a cross-linking agent), and hydroxypropyl methylcellulose (HPMC) or hydroxypropyl cellulose (HPC) polymers, as potential wound dressing materials based on their physicochemical properties and the sustain-release phenomenon. Materials and Methods: The physicochemical properties of the prepared hydrogel membranes were evaluated by several methods including Fourier transform infrared and differential scanning calorimetry. Different techniques were used to assess the swelling behavior, tensile strength and elongation, % moisture absorption, % moisture loss, water vapor transmission rate (WVTR), and microbial penetration for the hydrogel membranes. In vitro gatifloxacin release from the hydrogel membranes was examined using the United States Pharmacopeia XXIII dissolution apparatus. Four kinetics models (zero-order, first-order, Higuchi equation, and Korsmeyer- Peppas equation) were applied to study drug release kinetics. Results: The addition of glycerol, glutaraldehyde, HPMC, and HPC polymers resulted in a considerable increase in the tensile strength and flexibility/elasticity of the hydrogel membranes. WVTR results suggest that hydrated hydrogel membranes can facilitate water vapor transfer. None of the hydrogel membranes supported microbial growth. HPMC-treated and HPC-treated hydrogel membranes allow slow, but sustained, release of gatifloxacin for 48 h. Drug release kinetics revealed that both diffusion and dissolution play an important role in gatifloxacin release. Conclusions: Given their physicochemical properties and gatifloxacin release pattern, HPMC-treated and HPC-treated hydrogel membranes exhibit effective and sustained drug release. Furthermore, HPMC-treated and HPC-treated hydrogel membranes possess physiochemical properties that make them effective and safe wound dressing materials.PKP2022-10-25T08:40:14Z2022-10-25T08:40:14Z2016Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfPrabu D, Majdalawieh AF, Abu-Yousef IA, Inbasekaran K, Balasubramaniam T, Nallaperumal N, Gunasekar CJ. Preparation and characterization of gatifloxacin-loaded sodium alginate hydrogel membranes supplemented with hydroxypropyl methylcellulose and hydroxypropyl cellulose polymers for wound dressing. Int J Pharma Investig 2016;6:86-95.2230-9713http://hdl.handle.net/11073/2505110.4103/2230-973X.177810en_UShttps://doi.org/10.4103/2230-973X.177810oai:repository.aus.edu:11073/250512024-08-22T11:59:30Z |
| spellingShingle | Preparation and characterization of gatifloxacin-loaded sodium alginate hydrogel membranes supplemented with hydroxypropyl methylcellulose and hydroxypropyl cellulose polymers for wound dressing Prabu, Durai Gatifloxacin Hydrogel membrane In vitro drug release Sodium alginate Wound dressing |
| status_str | publishedVersion |
| title | Preparation and characterization of gatifloxacin-loaded sodium alginate hydrogel membranes supplemented with hydroxypropyl methylcellulose and hydroxypropyl cellulose polymers for wound dressing |
| title_full | Preparation and characterization of gatifloxacin-loaded sodium alginate hydrogel membranes supplemented with hydroxypropyl methylcellulose and hydroxypropyl cellulose polymers for wound dressing |
| title_fullStr | Preparation and characterization of gatifloxacin-loaded sodium alginate hydrogel membranes supplemented with hydroxypropyl methylcellulose and hydroxypropyl cellulose polymers for wound dressing |
| title_full_unstemmed | Preparation and characterization of gatifloxacin-loaded sodium alginate hydrogel membranes supplemented with hydroxypropyl methylcellulose and hydroxypropyl cellulose polymers for wound dressing |
| title_short | Preparation and characterization of gatifloxacin-loaded sodium alginate hydrogel membranes supplemented with hydroxypropyl methylcellulose and hydroxypropyl cellulose polymers for wound dressing |
| title_sort | Preparation and characterization of gatifloxacin-loaded sodium alginate hydrogel membranes supplemented with hydroxypropyl methylcellulose and hydroxypropyl cellulose polymers for wound dressing |
| topic | Gatifloxacin Hydrogel membrane In vitro drug release Sodium alginate Wound dressing |
| url | http://hdl.handle.net/11073/25051 |