Ultrasound-Triggered Liposomes Encapsulating Quantum Dots as Safe Fluorescent Markers for Colorectal Cancer
Quantum dots (QDs) are a promising tool to detect and monitor tumors. However, their small size allows them to accumulate in large quantities inside the healthy cells (in addition to the tumor cells), which increases their toxicity. In this study, we synthesized stealth liposomes encapsulating hydro...
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| مؤلفون آخرون: | , , , , , |
| التنسيق: | article |
| منشور في: |
2021
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/11073/21582 |
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| _version_ | 1864513439227969536 |
|---|---|
| author | Awad, Nahid S. |
| author2 | Haider, Mohamed Paul, Vinod AlSawaftah, Nour Majdi Jagal, Jayalakshmi Pasricha, Renu Husseini, Ghaleb |
| author2_role | author author author author author author |
| author_facet | Awad, Nahid S. Haider, Mohamed Paul, Vinod AlSawaftah, Nour Majdi Jagal, Jayalakshmi Pasricha, Renu Husseini, Ghaleb |
| author_role | author |
| dc.creator.none.fl_str_mv | Awad, Nahid S. Haider, Mohamed Paul, Vinod AlSawaftah, Nour Majdi Jagal, Jayalakshmi Pasricha, Renu Husseini, Ghaleb |
| dc.date.none.fl_str_mv | 2021-12-06T06:16:57Z 2021-12-06T06:16:57Z 2021 |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Awad, N.S.; Haider, M.; Paul, V.; AlSawaftah, N.M.; Jagal, J.; Pasricha, R.; Husseini, G.A. Ultrasound-Triggered Liposomes Encapsulating Quantum Dots as Safe Fluorescent Markers for Colorectal Cancer. Pharmaceutics 2021, 13, 2073. https://doi.org/10.3390/pharmaceutics13122073 1999-4923 http://hdl.handle.net/11073/21582 10.3390/ pharmaceutics13122073 |
| dc.language.none.fl_str_mv | en_US |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.relation.none.fl_str_mv | https://doi.org/10.3390/ pharmaceutics13122073 |
| dc.subject.none.fl_str_mv | Quantum dots Liposomes Low-frequency ultrasound Controlled release |
| dc.title.none.fl_str_mv | Ultrasound-Triggered Liposomes Encapsulating Quantum Dots as Safe Fluorescent Markers for Colorectal Cancer |
| dc.type.none.fl_str_mv | Peer-Reviewed Published version info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Quantum dots (QDs) are a promising tool to detect and monitor tumors. However, their small size allows them to accumulate in large quantities inside the healthy cells (in addition to the tumor cells), which increases their toxicity. In this study, we synthesized stealth liposomes encapsulating hydrophilic graphene quantum dots and triggered their release with ultrasound with the goal of developing a safer and well-controlled modality to deliver fluorescent markers to tumors. Our results confirmed the successful encapsulation of the QDs inside the core of the liposomes and showed no effect on the size or stability of the prepared liposomes. Our results also showed that low-frequency ultrasound is an effective method to release QDs encapsulated inside the liposomes in a spatially and temporally controlled manner to ensure the effective delivery of QDs to tumors while reducing their systemic toxicity. |
| format | article |
| id | aus_26684161c07c1d55883a0cd121e40afd |
| identifier_str_mv | Awad, N.S.; Haider, M.; Paul, V.; AlSawaftah, N.M.; Jagal, J.; Pasricha, R.; Husseini, G.A. Ultrasound-Triggered Liposomes Encapsulating Quantum Dots as Safe Fluorescent Markers for Colorectal Cancer. Pharmaceutics 2021, 13, 2073. https://doi.org/10.3390/pharmaceutics13122073 1999-4923 10.3390/ pharmaceutics13122073 |
| language_invalid_str_mv | en_US |
| network_acronym_str | aus |
| network_name_str | aus |
| oai_identifier_str | oai:repository.aus.edu:11073/21582 |
| publishDate | 2021 |
| publisher.none.fl_str_mv | MDPI |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| spelling | Ultrasound-Triggered Liposomes Encapsulating Quantum Dots as Safe Fluorescent Markers for Colorectal CancerAwad, Nahid S.Haider, MohamedPaul, VinodAlSawaftah, Nour MajdiJagal, JayalakshmiPasricha, RenuHusseini, GhalebQuantum dotsLiposomesLow-frequency ultrasoundControlled releaseQuantum dots (QDs) are a promising tool to detect and monitor tumors. However, their small size allows them to accumulate in large quantities inside the healthy cells (in addition to the tumor cells), which increases their toxicity. In this study, we synthesized stealth liposomes encapsulating hydrophilic graphene quantum dots and triggered their release with ultrasound with the goal of developing a safer and well-controlled modality to deliver fluorescent markers to tumors. Our results confirmed the successful encapsulation of the QDs inside the core of the liposomes and showed no effect on the size or stability of the prepared liposomes. Our results also showed that low-frequency ultrasound is an effective method to release QDs encapsulated inside the liposomes in a spatially and temporally controlled manner to ensure the effective delivery of QDs to tumors while reducing their systemic toxicity.American University of SharjahSheikh Hamdan Award for Medical SciencesUniversity of SharjahMDPI2021-12-06T06:16:57Z2021-12-06T06:16:57Z2021Peer-ReviewedPublished versioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfAwad, N.S.; Haider, M.; Paul, V.; AlSawaftah, N.M.; Jagal, J.; Pasricha, R.; Husseini, G.A. Ultrasound-Triggered Liposomes Encapsulating Quantum Dots as Safe Fluorescent Markers for Colorectal Cancer. Pharmaceutics 2021, 13, 2073. https://doi.org/10.3390/pharmaceutics131220731999-4923http://hdl.handle.net/11073/2158210.3390/ pharmaceutics13122073en_UShttps://doi.org/10.3390/ pharmaceutics13122073oai:repository.aus.edu:11073/215822024-08-22T12:04:13Z |
| spellingShingle | Ultrasound-Triggered Liposomes Encapsulating Quantum Dots as Safe Fluorescent Markers for Colorectal Cancer Awad, Nahid S. Quantum dots Liposomes Low-frequency ultrasound Controlled release |
| status_str | publishedVersion |
| title | Ultrasound-Triggered Liposomes Encapsulating Quantum Dots as Safe Fluorescent Markers for Colorectal Cancer |
| title_full | Ultrasound-Triggered Liposomes Encapsulating Quantum Dots as Safe Fluorescent Markers for Colorectal Cancer |
| title_fullStr | Ultrasound-Triggered Liposomes Encapsulating Quantum Dots as Safe Fluorescent Markers for Colorectal Cancer |
| title_full_unstemmed | Ultrasound-Triggered Liposomes Encapsulating Quantum Dots as Safe Fluorescent Markers for Colorectal Cancer |
| title_short | Ultrasound-Triggered Liposomes Encapsulating Quantum Dots as Safe Fluorescent Markers for Colorectal Cancer |
| title_sort | Ultrasound-Triggered Liposomes Encapsulating Quantum Dots as Safe Fluorescent Markers for Colorectal Cancer |
| topic | Quantum dots Liposomes Low-frequency ultrasound Controlled release |
| url | http://hdl.handle.net/11073/21582 |